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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DEF All Species: 15.76
Human Site: S271 Identified Species: 28.89
UniProt: Q68CQ4 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q68CQ4 NP_055203.4 756 87055 S271 F L S G P Q K S S S P F T P L
Chimpanzee Pan troglodytes XP_525053 756 87125 S271 F L S G P Q K S S S P F T P L
Rhesus Macaque Macaca mulatta XP_001109922 755 86704 S270 F L S G P Q K S S S P F T P L
Dog Lupus familis XP_547394 639 73475 H200 Y C L H A I N H V L K A N A Q
Cat Felis silvestris
Mouse Mus musculus Q8BTT6 772 88799 S287 F L S G P Q K S N S S F T P L
Rat Rattus norvegicus Q5M9G7 763 87806 Q276 F L S G P G P Q K S S S C F T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509371 772 89238 Q288 F L S A A G K Q K G F F T P L
Chicken Gallus gallus Q5ZLG3 772 88932 S287 L S S A S K P S D S F F T P L
Frog Xenopus laevis NP_001091284 767 88492 N283 S P F L S A P N E Q H F T P L
Zebra Danio Brachydanio rerio Q6PEH4 753 86784 A268 L L N L P F G A A T D V T E L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611851 700 81542 R261 K V R S L I L R N N E K V S A
Honey Bee Apis mellifera XP_395073 700 81460 L260 L H T I N H V L K T R T K V L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40498 721 83973 K273 Y E Y D S Y E K D E D E Y R D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 97.7 78 N.A. 86.2 87.8 N.A. 74.3 68.9 68 54.5 N.A. 35.3 42.2 N.A. N.A.
Protein Similarity: 100 99.7 98.4 81.3 N.A. 91.1 93.3 N.A. 85.6 81.3 82 71 N.A. 56.3 62.8 N.A. N.A.
P-Site Identity: 100 100 100 0 N.A. 86.6 40 N.A. 53.3 46.6 26.6 26.6 N.A. 0 6.6 N.A. N.A.
P-Site Similarity: 100 100 100 6.6 N.A. 93.3 40 N.A. 53.3 53.3 33.3 53.3 N.A. 20 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 31.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 16 16 8 0 8 8 0 0 8 0 8 8 % A
% Cys: 0 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 0 8 0 0 0 0 16 0 16 0 0 0 8 % D
% Glu: 0 8 0 0 0 0 8 0 8 8 8 8 0 8 0 % E
% Phe: 47 0 8 0 0 8 0 0 0 0 16 54 0 8 0 % F
% Gly: 0 0 0 39 0 16 8 0 0 8 0 0 0 0 0 % G
% His: 0 8 0 8 0 8 0 8 0 0 8 0 0 0 0 % H
% Ile: 0 0 0 8 0 16 0 0 0 0 0 0 0 0 0 % I
% Lys: 8 0 0 0 0 8 39 8 24 0 8 8 8 0 0 % K
% Leu: 24 54 8 16 8 0 8 8 0 8 0 0 0 0 70 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 8 0 8 8 16 8 0 0 8 0 0 % N
% Pro: 0 8 0 0 47 0 24 0 0 0 24 0 0 54 0 % P
% Gln: 0 0 0 0 0 31 0 16 0 8 0 0 0 0 8 % Q
% Arg: 0 0 8 0 0 0 0 8 0 0 8 0 0 8 0 % R
% Ser: 8 8 54 8 24 0 0 39 24 47 16 8 0 8 0 % S
% Thr: 0 0 8 0 0 0 0 0 0 16 0 8 62 0 8 % T
% Val: 0 8 0 0 0 0 8 0 8 0 0 8 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 16 0 8 0 0 8 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _