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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF
All Species:
27.58
Human Site:
S64
Identified Species:
50.56
UniProt:
Q68CQ4
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q68CQ4
NP_055203.4
756
87055
S64
D
S
E
S
D
S
E
S
E
P
Q
Q
V
S
G
Chimpanzee
Pan troglodytes
XP_525053
756
87125
S64
D
S
E
S
D
S
E
S
E
P
E
Q
V
S
G
Rhesus Macaque
Macaca mulatta
XP_001109922
755
86704
E63
S
D
S
E
S
E
S
E
S
E
P
E
Q
V
S
Dog
Lupus familis
XP_547394
639
73475
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTT6
772
88799
S64
H
S
E
S
E
S
E
S
E
Q
E
H
V
S
G
Rat
Rattus norvegicus
Q5M9G7
763
87806
S64
H
S
E
S
E
S
E
S
E
Q
E
H
V
S
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509371
772
89238
S66
S
S
D
S
D
A
E
S
E
S
E
Q
V
S
G
Chicken
Gallus gallus
Q5ZLG3
772
88932
T62
S
A
E
S
D
S
E
T
E
V
E
Q
V
S
V
Frog
Xenopus laevis
NP_001091284
767
88492
S65
R
S
E
S
E
A
E
S
E
P
E
Q
V
N
M
Zebra Danio
Brachydanio rerio
Q6PEH4
753
86784
S62
E
P
D
S
E
D
D
S
D
A
E
Q
P
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611851
700
81542
L61
E
Y
E
P
V
A
E
L
L
P
E
I
Q
D
D
Honey Bee
Apis mellifera
XP_395073
700
81460
S60
P
L
Q
N
L
L
S
S
F
S
N
T
T
N
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40498
721
83973
E72
D
D
F
D
I
E
D
E
E
G
K
K
E
K
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.7
78
N.A.
86.2
87.8
N.A.
74.3
68.9
68
54.5
N.A.
35.3
42.2
N.A.
N.A.
Protein Similarity:
100
99.7
98.4
81.3
N.A.
91.1
93.3
N.A.
85.6
81.3
82
71
N.A.
56.3
62.8
N.A.
N.A.
P-Site Identity:
100
93.3
0
0
N.A.
66.6
66.6
N.A.
66.6
60
60
26.6
N.A.
20
6.6
N.A.
N.A.
P-Site Similarity:
100
100
6.6
0
N.A.
80
80
N.A.
86.6
80
86.6
66.6
N.A.
40
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
24
0
0
0
8
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
24
16
16
8
31
8
16
0
8
0
0
0
0
8
8
% D
% Glu:
16
0
54
8
31
16
62
16
62
8
62
8
8
0
0
% E
% Phe:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
39
% G
% His:
16
0
0
0
0
0
0
0
0
0
0
16
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
8
8
0
8
0
% K
% Leu:
0
8
0
0
8
8
0
8
8
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
8
0
0
0
0
0
0
8
0
0
16
0
% N
% Pro:
8
8
0
8
0
0
0
0
0
31
8
0
8
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
16
8
47
16
0
0
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
24
47
8
62
8
39
16
62
8
16
0
0
0
54
8
% S
% Thr:
0
0
0
0
0
0
0
8
0
0
0
8
8
0
0
% T
% Val:
0
0
0
0
8
0
0
0
0
8
0
0
54
8
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _