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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF
All Species:
22.12
Human Site:
T235
Identified Species:
40.56
UniProt:
Q68CQ4
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q68CQ4
NP_055203.4
756
87055
T235
S
K
F
Q
K
L
E
T
F
K
P
P
K
D
I
Chimpanzee
Pan troglodytes
XP_525053
756
87125
T235
S
K
F
Q
K
L
E
T
F
K
P
P
K
D
I
Rhesus Macaque
Macaca mulatta
XP_001109922
755
86704
T234
S
K
F
Q
K
L
E
T
F
K
P
P
K
D
I
Dog
Lupus familis
XP_547394
639
73475
E164
P
F
T
P
L
Q
K
E
L
F
L
I
M
N
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTT6
772
88799
T251
S
K
F
Q
K
T
E
T
F
K
P
P
K
D
I
Rat
Rattus norvegicus
Q5M9G7
763
87806
T240
S
K
F
Q
K
M
E
T
F
K
P
P
K
D
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509371
772
89238
T252
S
T
F
Q
K
V
E
T
F
K
P
P
K
E
V
Chicken
Gallus gallus
Q5ZLG3
772
88932
L251
T
L
E
K
H
T
T
L
K
P
D
K
E
F
S
Frog
Xenopus laevis
NP_001091284
767
88492
V247
I
S
S
F
L
P
E
V
Q
P
L
K
P
E
K
Zebra Danio
Brachydanio rerio
Q6PEH4
753
86784
C232
L
G
V
L
Q
C
M
C
P
L
E
R
F
P
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611851
700
81542
Q225
F
Y
I
A
N
N
Y
Q
D
I
Y
Y
P
H
R
Honey Bee
Apis mellifera
XP_395073
700
81460
L224
M
T
P
L
Q
K
E
L
F
S
I
I
N
N
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40498
721
83973
N237
K
Q
R
L
K
V
Q
N
G
L
L
D
K
K
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.7
78
N.A.
86.2
87.8
N.A.
74.3
68.9
68
54.5
N.A.
35.3
42.2
N.A.
N.A.
Protein Similarity:
100
99.7
98.4
81.3
N.A.
91.1
93.3
N.A.
85.6
81.3
82
71
N.A.
56.3
62.8
N.A.
N.A.
P-Site Identity:
100
100
100
0
N.A.
93.3
93.3
N.A.
73.3
0
6.6
0
N.A.
0
13.3
N.A.
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
93.3
100
N.A.
93.3
20
13.3
6.6
N.A.
0
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
8
0
8
8
0
39
0
% D
% Glu:
0
0
8
0
0
0
62
8
0
0
8
0
8
16
0
% E
% Phe:
8
8
47
8
0
0
0
0
54
8
0
0
8
8
0
% F
% Gly:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
8
0
8
0
0
0
0
0
0
8
8
16
0
0
39
% I
% Lys:
8
39
0
8
54
8
8
0
8
47
0
16
54
8
8
% K
% Leu:
8
8
0
24
16
24
0
16
8
16
24
0
0
0
0
% L
% Met:
8
0
0
0
0
8
8
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
0
8
8
0
8
0
0
0
0
8
16
0
% N
% Pro:
8
0
8
8
0
8
0
0
8
16
47
47
16
8
0
% P
% Gln:
0
8
0
47
16
8
8
8
8
0
0
0
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
8
% R
% Ser:
47
8
8
0
0
0
0
0
0
8
0
0
0
0
16
% S
% Thr:
8
16
8
0
0
16
8
47
0
0
0
0
0
0
8
% T
% Val:
0
0
8
0
0
16
0
8
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
8
0
0
0
8
8
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _