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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF
All Species:
39.7
Human Site:
Y677
Identified Species:
72.78
UniProt:
Q68CQ4
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q68CQ4
NP_055203.4
756
87055
Y677
R
F
H
F
Y
K
R
Y
T
I
K
G
I
R
N
Chimpanzee
Pan troglodytes
XP_525053
756
87125
Y677
R
F
H
F
Y
K
R
Y
T
I
K
G
I
R
N
Rhesus Macaque
Macaca mulatta
XP_001109922
755
86704
Y676
R
F
H
F
Y
K
R
Y
T
I
K
G
I
R
N
Dog
Lupus familis
XP_547394
639
73475
R566
R
Y
T
I
K
G
I
R
N
L
I
F
Y
E
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTT6
772
88799
Y693
R
F
H
F
Y
K
R
Y
T
I
K
G
I
R
N
Rat
Rattus norvegicus
Q5M9G7
763
87806
Y684
R
F
H
F
Y
K
R
Y
T
I
K
G
I
R
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509371
772
89238
Y693
R
F
H
F
Y
K
R
Y
T
I
K
G
I
R
N
Chicken
Gallus gallus
Q5ZLG3
772
88932
Y692
R
F
H
F
Y
K
R
Y
T
I
K
G
I
R
N
Frog
Xenopus laevis
NP_001091284
767
88492
Y687
R
F
H
F
Y
K
R
Y
T
L
K
G
I
R
N
Zebra Danio
Brachydanio rerio
Q6PEH4
753
86784
Y669
R
F
H
F
Y
K
R
Y
T
I
K
G
I
H
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611851
700
81542
I627
I
K
G
I
R
N
L
I
M
Y
Q
P
P
N
F
Honey Bee
Apis mellifera
XP_395073
700
81460
I627
V
K
G
I
R
H
I
I
F
Y
A
P
P
I
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40498
721
83973
Y643
R
L
H
H
Y
R
R
Y
E
I
K
G
V
K
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.7
78
N.A.
86.2
87.8
N.A.
74.3
68.9
68
54.5
N.A.
35.3
42.2
N.A.
N.A.
Protein Similarity:
100
99.7
98.4
81.3
N.A.
91.1
93.3
N.A.
85.6
81.3
82
71
N.A.
56.3
62.8
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
100
100
N.A.
100
100
93.3
93.3
N.A.
0
0
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
6.6
0
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% E
% Phe:
0
70
0
70
0
0
0
0
8
0
0
8
0
0
16
% F
% Gly:
0
0
16
0
0
8
0
0
0
0
0
77
0
0
0
% G
% His:
0
0
77
8
0
8
0
0
0
0
0
0
0
8
0
% H
% Ile:
8
0
0
24
0
0
16
16
0
70
8
0
70
8
0
% I
% Lys:
0
16
0
0
8
70
0
0
0
0
77
0
0
8
0
% K
% Leu:
0
8
0
0
0
0
8
0
0
16
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
8
0
0
0
0
8
70
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
16
16
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
85
0
0
0
16
8
77
8
0
0
0
0
0
62
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% S
% Thr:
0
0
8
0
0
0
0
0
70
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
77
0
0
77
0
16
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _