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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ISM2
All Species:
3.03
Human Site:
S452
Identified Species:
7.41
UniProt:
Q6H9L7
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6H9L7
NP_872315.2
571
63906
S452
Q
D
E
H
Q
G
R
S
F
R
W
R
D
A
S
Chimpanzee
Pan troglodytes
XP_525268
582
65976
D463
F
D
R
I
K
R
K
D
F
R
W
K
D
A
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542888
464
52096
F346
D
R
I
K
R
K
D
F
R
W
K
D
A
S
G
Cat
Felis silvestris
Mouse
Mus musculus
A2ATD1
454
51126
F336
D
R
I
K
R
K
D
F
R
W
K
D
A
S
G
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515088
433
49392
D314
Y
D
R
V
K
R
K
D
F
R
W
K
D
A
S
Chicken
Gallus gallus
XP_426452
491
55855
F373
D
E
R
Q
G
K
S
F
R
W
R
D
A
S
G
Frog
Xenopus laevis
Q8QFV1
449
50956
F331
D
R
I
K
R
K
D
F
R
W
K
D
A
S
G
Zebra Danio
Brachydanio rerio
Q5EGE1
461
51157
F343
D
A
N
T
K
R
N
F
R
W
K
D
A
S
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120589
455
53322
Y336
W
D
E
K
R
M
K
Y
F
R
W
R
D
V
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001198390
398
44790
F280
D
P
Q
Q
G
R
E
F
H
W
I
E
Q
D
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32.4
N.A.
39.7
N.A.
38.3
N.A.
N.A.
37.1
46.9
37.4
38.1
N.A.
N.A.
24.3
N.A.
25.3
Protein Similarity:
100
46.7
N.A.
51.8
N.A.
51.1
N.A.
N.A.
48.1
59.8
50.9
51.3
N.A.
N.A.
40.4
N.A.
41.1
P-Site Identity:
100
46.6
N.A.
0
N.A.
0
N.A.
N.A.
46.6
0
0
0
N.A.
N.A.
53.3
N.A.
0
P-Site Similarity:
100
66.6
N.A.
13.3
N.A.
13.3
N.A.
N.A.
66.6
13.3
13.3
13.3
N.A.
N.A.
66.6
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
0
0
0
0
0
50
30
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
60
40
0
0
0
0
30
20
0
0
0
50
40
10
0
% D
% Glu:
0
10
20
0
0
0
10
0
0
0
0
10
0
0
0
% E
% Phe:
10
0
0
0
0
0
0
60
40
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
20
10
0
0
0
0
0
0
0
0
50
% G
% His:
0
0
0
10
0
0
0
0
10
0
0
0
0
0
0
% H
% Ile:
0
0
30
10
0
0
0
0
0
0
10
0
0
0
0
% I
% Lys:
0
0
0
40
30
40
30
0
0
0
40
20
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
10
% P
% Gln:
10
0
10
20
10
0
0
0
0
0
0
0
10
0
0
% Q
% Arg:
0
30
30
0
40
40
10
0
50
40
10
20
0
0
0
% R
% Ser:
0
0
0
0
0
0
10
10
0
0
0
0
0
50
40
% S
% Thr:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
10
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
10
0
0
0
0
0
0
0
0
60
40
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _