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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ISM2 All Species: 11.52
Human Site: S478 Identified Species: 28.15
UniProt: Q6H9L7 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6H9L7 NP_872315.2 571 63906 S478 T A R F C L R S M L S G E S S
Chimpanzee Pan troglodytes XP_525268 582 65976 S489 T A R Y C I R S M L S L E S T
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542888 464 52096 M372 A R Y C I R S M L S L E S T T
Cat Felis silvestris
Mouse Mus musculus A2ATD1 454 51126 M362 A R Y C I R S M L S L E S T T
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515088 433 49392 S340 T A R Y C V R S M L S L E S T
Chicken Gallus gallus XP_426452 491 55855 M399 A R F C L R S M L S L D S T T
Frog Xenopus laevis Q8QFV1 449 50956 M357 A R Y C I R S M L S L E S T T
Zebra Danio Brachydanio rerio Q5EGE1 461 51157 M369 A R Y C I R S M L T L E S T T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120589 455 53322 S362 G A T Y C I R S L L T Q G S G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001198390 398 44790 L306 A Q S C I Q S L R S Y H S T S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 32.4 N.A. 39.7 N.A. 38.3 N.A. N.A. 37.1 46.9 37.4 38.1 N.A. N.A. 24.3 N.A. 25.3
Protein Similarity: 100 46.7 N.A. 51.8 N.A. 51.1 N.A. N.A. 48.1 59.8 50.9 51.3 N.A. N.A. 40.4 N.A. 41.1
P-Site Identity: 100 73.3 N.A. 0 N.A. 0 N.A. N.A. 73.3 0 0 0 N.A. N.A. 40 N.A. 6.6
P-Site Similarity: 100 93.3 N.A. 20 N.A. 20 N.A. N.A. 93.3 20 20 20 N.A. N.A. 66.6 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 60 40 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 60 40 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 40 30 0 0 % E
% Phe: 0 0 10 10 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 0 0 0 0 0 0 0 0 0 10 10 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % H
% Ile: 0 0 0 0 50 20 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 10 10 0 10 60 40 50 20 0 0 0 % L
% Met: 0 0 0 0 0 0 0 50 30 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 10 0 0 0 10 0 0 0 0 0 10 0 0 0 % Q
% Arg: 0 50 30 0 0 50 40 0 10 0 0 0 0 0 0 % R
% Ser: 0 0 10 0 0 0 60 40 0 50 30 0 60 40 20 % S
% Thr: 30 0 10 0 0 0 0 0 0 10 10 0 0 60 70 % T
% Val: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 40 30 0 0 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _