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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ISM2 All Species: 3.94
Human Site: T394 Identified Species: 9.63
UniProt: Q6H9L7 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6H9L7 NP_872315.2 571 63906 T394 K L L A R N A T D M H D Q D V
Chimpanzee Pan troglodytes XP_525268 582 65976 T405 G S E E F N A T K L F E V D T
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542888 464 52096 K288 S E E F N A T K L F E V D T D
Cat Felis silvestris
Mouse Mus musculus A2ATD1 454 51126 K278 S E E F N A T K L F E V D M D
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515088 433 49392 T256 G S E E F N A T K L F E V D M
Chicken Gallus gallus XP_426452 491 55855 E315 F R S D N T T E L F N S D V D
Frog Xenopus laevis Q8QFV1 449 50956 K273 N E D F N A T K L F G V D T D
Zebra Danio Brachydanio rerio Q5EGE1 461 51157 E285 T E E F N A T E L F G V D T D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120589 455 53322 E278 D E R N I F K E L N F V N G T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001198390 398 44790 V222 Q G F T I D V V D E I A D A I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 32.4 N.A. 39.7 N.A. 38.3 N.A. N.A. 37.1 46.9 37.4 38.1 N.A. N.A. 24.3 N.A. 25.3
Protein Similarity: 100 46.7 N.A. 51.8 N.A. 51.1 N.A. N.A. 48.1 59.8 50.9 51.3 N.A. N.A. 40.4 N.A. 41.1
P-Site Identity: 100 26.6 N.A. 0 N.A. 0 N.A. N.A. 26.6 0 0 0 N.A. N.A. 0 N.A. 6.6
P-Site Similarity: 100 40 N.A. 0 N.A. 0 N.A. N.A. 46.6 6.6 0 0 N.A. N.A. 0 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 0 40 30 0 0 0 0 10 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 10 10 0 10 0 0 20 0 0 10 60 30 50 % D
% Glu: 0 50 50 20 0 0 0 30 0 10 20 20 0 0 0 % E
% Phe: 10 0 10 40 20 10 0 0 0 50 30 0 0 0 0 % F
% Gly: 20 10 0 0 0 0 0 0 0 0 20 0 0 10 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % H
% Ile: 0 0 0 0 20 0 0 0 0 0 10 0 0 0 10 % I
% Lys: 10 0 0 0 0 0 10 30 20 0 0 0 0 0 0 % K
% Leu: 0 10 10 0 0 0 0 0 60 20 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 10 0 0 0 10 10 % M
% Asn: 10 0 0 10 50 30 0 0 0 10 10 0 10 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 10 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % Q
% Arg: 0 10 10 0 10 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 20 20 10 0 0 0 0 0 0 0 0 10 0 0 0 % S
% Thr: 10 0 0 10 0 10 50 30 0 0 0 0 0 30 20 % T
% Val: 0 0 0 0 0 0 10 10 0 0 0 50 20 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _