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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIGIRR All Species: 1.52
Human Site: S367 Identified Species: 8.33
UniProt: Q6IA17 Number Species: 4
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6IA17 NP_001128525.1 410 45707 S367 G P V F G E P S A P P H T S G
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_549165 708 81157 N659 L P V P S L G N H H T Y C N L
Cat Felis silvestris
Mouse Mus musculus Q9JLZ8 409 46140 P366 G P V F G E P P T P L Q E T R
Rat Rattus norvegicus Q4V892 409 46152 P366 G P V F G E P P T P L H E S K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio B6ZK77 700 80295 S635 G Y E Y D I P S S G T L P P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 20.3 N.A. 81.2 82.1 N.A. N.A. N.A. N.A. 20.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 N.A. N.A. 32.6 N.A. 88.2 88.2 N.A. N.A. N.A. N.A. 32.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 N.A. N.A. 13.3 N.A. 53.3 66.6 N.A. N.A. N.A. N.A. 20 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 N.A. N.A. 33.3 N.A. 60 66.6 N.A. N.A. N.A. N.A. 33.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 20 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 % C
% Asp: 0 0 0 0 20 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 20 0 0 60 0 0 0 0 0 0 40 0 0 % E
% Phe: 0 0 0 60 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 80 0 0 0 60 0 20 0 0 20 0 0 0 0 20 % G
% His: 0 0 0 0 0 0 0 0 20 20 0 40 0 0 0 % H
% Ile: 0 0 0 0 0 20 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20 % K
% Leu: 20 0 0 0 0 20 0 0 0 0 40 20 0 0 40 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 20 0 0 0 0 0 20 0 % N
% Pro: 0 80 0 20 0 0 80 40 0 60 20 0 20 20 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 20 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20 % R
% Ser: 0 0 0 0 20 0 0 40 20 0 0 0 0 40 0 % S
% Thr: 0 0 0 0 0 0 0 0 40 0 40 0 20 20 0 % T
% Val: 0 0 80 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 20 0 20 0 0 0 0 0 0 0 20 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _