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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TWF2 All Species: 39.7
Human Site: S274 Identified Species: 79.39
UniProt: Q6IBS0 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6IBS0 NP_009215.1 349 39548 S274 K E R M L Y S S C K S R L L D
Chimpanzee Pan troglodytes XP_001171340 1325 149159 S274 K E R M L Y S S C K S R L L D
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_859685 349 39451 S274 K E R M L Y S S C K S R L L D
Cat Felis silvestris
Mouse Mus musculus Q9Z0P5 349 39452 S274 K E R M L Y S S C K S R L L D
Rat Rattus norvegicus Q5RJR2 350 40072 S274 R E R M L Y S S C K S P L L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510564 313 35921 A266 K I E I G D G A E L T A D F L
Chicken Gallus gallus Q5ZM35 349 39817 S274 K E R M L Y S S C K S R L L D
Frog Xenopus laevis Q7ZXP0 349 39859 S274 K E R M L Y S S C K N R L L D
Zebra Danio Brachydanio rerio Q6GMH3 347 39840 S272 K E R M L Y S S C K S R L L D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VFM9 343 39052 S274 R E R M M Y S S C K A P F L D
Honey Bee Apis mellifera XP_393653 350 39782 S275 K E R M L Y S S C K A P L L E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53250 332 37052 K271 N G F I N Y L K N D Q K I A F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 26 N.A. 96.2 N.A. 96.5 64.8 N.A. 76.5 83.9 79.6 71.9 N.A. 49.2 51.7 N.A. N.A.
Protein Similarity: 100 26.2 N.A. 97.7 N.A. 98.8 84.5 N.A. 84.2 93.4 91.6 85.3 N.A. 67.6 72.8 N.A. N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 100 86.6 N.A. 6.6 100 93.3 100 N.A. 66.6 80 N.A. N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 93.3 N.A. 26.6 100 100 100 N.A. 86.6 93.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.9 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 9 0 0 17 9 0 9 0 % A
% Cys: 0 0 0 0 0 0 0 0 84 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 9 0 0 0 9 0 0 9 0 75 % D
% Glu: 0 84 9 0 0 0 0 0 9 0 0 0 0 0 9 % E
% Phe: 0 0 9 0 0 0 0 0 0 0 0 0 9 9 9 % F
% Gly: 0 9 0 0 9 0 9 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 9 0 17 0 0 0 0 0 0 0 0 9 0 0 % I
% Lys: 75 0 0 0 0 0 0 9 0 84 0 9 0 0 0 % K
% Leu: 0 0 0 0 75 0 9 0 0 9 0 0 75 84 9 % L
% Met: 0 0 0 84 9 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 0 0 0 9 0 0 0 9 0 9 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 25 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % Q
% Arg: 17 0 84 0 0 0 0 0 0 0 0 59 0 0 0 % R
% Ser: 0 0 0 0 0 0 84 84 0 0 59 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 92 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _