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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TYW3 All Species: 4.55
Human Site: T227 Identified Species: 11.11
UniProt: Q6IPR3 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6IPR3 NP_612476.1 259 29794 T227 K K R N P E K T R A Q C I T K
Chimpanzee Pan troglodytes XP_001167649 259 29688 T227 K K R N P E K T R A Q C I T K
Rhesus Macaque Macaca mulatta XP_001100269 258 29422 A227 K Q R N P E K A H A Q C I T K
Dog Lupus familis XP_537110 218 24675 A188 K K R N P E A A C G K C I T E
Cat Felis silvestris
Mouse Mus musculus Q8BSA9 257 28557 A227 N R R S Q G K A Q G P S T T E
Rat Rattus norvegicus XP_001080203 258 28574 A227 N Q R K Q G K A C D P S T T E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505991 369 41449 D229 R N P E R A Q D S R V S P E K
Chicken Gallus gallus XP_422546 250 27520 Q217 R R K R R T V Q T Q D V L P S
Frog Xenopus laevis Q641F8 251 28675 R220 S C V Y V R R R K R K D R S R
Zebra Danio Brachydanio rerio Q6DHJ1 251 28779 D222 R R R K R T Q D V S V T D S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 91.5 68.7 N.A. 70.2 69.5 N.A. 35.7 52.9 50.1 50.9 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.6 95.3 76 N.A. 80.6 78.7 N.A. 49.3 70.6 72.1 71.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 80 60 N.A. 20 20 N.A. 6.6 0 0 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 86.6 73.3 N.A. 46.6 33.3 N.A. 20 26.6 33.3 40 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 10 40 0 30 0 0 0 0 0 % A
% Cys: 0 10 0 0 0 0 0 0 20 0 0 40 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 20 0 10 10 10 10 0 0 % D
% Glu: 0 0 0 10 0 40 0 0 0 0 0 0 0 10 30 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 20 0 0 0 20 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 40 0 0 % I
% Lys: 40 30 10 20 0 0 50 0 10 0 20 0 0 0 40 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 20 10 0 40 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 10 0 40 0 0 0 0 0 20 0 10 10 0 % P
% Gln: 0 20 0 0 20 0 20 10 10 10 30 0 0 0 0 % Q
% Arg: 30 30 70 10 30 10 10 10 20 20 0 0 10 0 10 % R
% Ser: 10 0 0 10 0 0 0 0 10 10 0 30 0 20 20 % S
% Thr: 0 0 0 0 0 20 0 20 10 0 0 10 20 60 0 % T
% Val: 0 0 10 0 10 0 10 0 10 0 20 10 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _