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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF5AL1 All Species: 47.27
Human Site: T9 Identified Species: 74.29
UniProt: Q6IS14 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6IS14 NP_001093162.1 154 16773 T9 A D D L D F E T G D A G A S A
Chimpanzee Pan troglodytes XP_001174773 286 30517 T141 A D D L D F E T G D A G A S A
Rhesus Macaque Macaca mulatta XP_001118011 190 21255 T45 A D D L D F E T G D A G A S A
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus XP_001472697 357 39965 T9 A D D L D F E T G D A G P S A
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q07460 153 16702 T9 A D E L D F T T G D A G A S S
Frog Xenopus laevis NP_001080536 154 16686 S9 A D D I D F T S G D A G A S S
Zebra Danio Brachydanio rerio NP_998350 155 16861 S10 D P D L D F A S G D A G A S A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9GU68 159 17573 T10 E L D D Q F E T T D S G A S T
Honey Bee Apis mellifera XP_624951 160 17574 T11 I E D T H F E T G D S G A S V
Nematode Worm Caenorhab. elegans Q20751 161 17935 T13 H D D E H F H T G D S G A A A
Sea Urchin Strong. purpuratus XP_785877 156 17276 S11 N H D E Y F E S G D S G A S K
Poplar Tree Populus trichocarpa
Maize Zea mays P80639 160 17478 K12 E E H H F E S K A D A G A S K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9XI91 158 17342 S10 D E E H H F E S S D A G A S K
Baker's Yeast Sacchar. cerevisiae P23301 157 17096 T10 D E E H T F E T A D A G S S A
Red Bread Mold Neurospora crassa P38672 163 18017 S16 Q H E H T F D S V D A G A S A
Conservation
Percent
Protein Identity: 100 52.7 79.4 N.A. N.A. 39.7 N.A. N.A. N.A. 82.4 81.1 80 N.A. 64.7 66.8 59 63.4
Protein Similarity: 100 52.7 79.4 N.A. N.A. 41.4 N.A. N.A. N.A. 90.2 91.5 90.3 N.A. 80.5 79.3 73.9 77.5
P-Site Identity: 100 100 100 N.A. N.A. 93.3 N.A. N.A. N.A. 80 73.3 73.3 N.A. 53.3 60 60 53.3
P-Site Similarity: 100 100 100 N.A. N.A. 93.3 N.A. N.A. N.A. 93.3 93.3 80 N.A. 60 73.3 73.3 66.6
Percent
Protein Identity: N.A. 51.2 N.A. 53.8 60.5 58.2
Protein Similarity: N.A. 71.2 N.A. 74 80.8 73.6
P-Site Identity: N.A. 33.3 N.A. 46.6 53.3 46.6
P-Site Similarity: N.A. 40 N.A. 66.6 73.3 66.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 40 0 0 0 0 0 7 0 14 0 74 0 87 7 54 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 20 47 67 7 47 0 7 0 0 100 0 0 0 0 0 % D
% Glu: 14 27 27 14 0 7 60 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 7 94 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 67 0 0 100 0 0 0 % G
% His: 7 14 7 27 20 0 7 0 0 0 0 0 0 0 0 % H
% Ile: 7 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 20 % K
% Leu: 0 7 0 40 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 7 0 0 0 0 0 0 0 0 0 0 7 0 0 % P
% Gln: 7 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 7 34 7 0 27 0 7 94 14 % S
% Thr: 0 0 0 7 14 0 14 60 7 0 0 0 0 0 7 % T
% Val: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _