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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE12
All Species:
22.73
Human Site:
S192
Identified Species:
35.71
UniProt:
Q6L8Q7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6L8Q7
NP_808881.3
609
67352
S192
L
E
F
G
D
P
A
S
S
L
F
R
W
Y
K
Chimpanzee
Pan troglodytes
XP_517033
609
67371
S192
L
E
F
G
D
P
A
S
S
L
F
R
W
Y
K
Rhesus Macaque
Macaca mulatta
XP_001099328
609
67247
S192
L
E
F
G
D
P
A
S
S
L
F
R
W
Y
K
Dog
Lupus familis
XP_541830
616
67598
S199
L
E
F
G
D
P
A
S
S
L
F
R
W
Y
K
Cat
Felis silvestris
Mouse
Mus musculus
Q3TIU4
608
67495
S191
V
E
F
G
D
P
A
S
S
V
F
R
W
Y
K
Rat
Rattus norvegicus
Q6AXQ5
608
67158
S191
L
E
F
G
D
P
A
S
S
V
F
R
W
Y
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511095
639
68679
A203
L
E
F
A
E
P
H
A
S
L
F
R
W
F
K
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001038753
591
65883
P169
M
A
G
F
P
V
C
P
K
I
E
I
E
F
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_723735
564
64146
V168
P
T
D
T
D
W
E
V
C
G
E
G
F
Q
Y
Honey Bee
Apis mellifera
XP_001121328
441
50969
I45
S
I
K
N
S
T
D
I
K
L
V
I
F
D
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784408
1354
152949
W924
T
E
F
V
K
E
E
W
S
T
Y
Q
W
F
R
Poplar Tree
Populus trichocarpa
XP_002323345
603
66902
D186
K
T
Y
T
P
S
A
D
D
I
G
H
V
L
K
Maize
Zea mays
NP_001146094
605
67010
A188
S
R
T
Y
T
P
T
A
D
D
I
G
H
A
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F8
603
67035
A183
C
K
T
Y
T
P
T
A
D
D
I
S
H
V
L
Baker's Yeast
Sacchar. cerevisiae
P31384
837
94681
A351
L
Q
I
F
N
I
S
A
N
I
F
K
Y
D
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.8
92.3
N.A.
88.3
89.8
N.A.
74.3
N.A.
N.A.
54.6
N.A.
33.9
29.3
N.A.
20.3
Protein Similarity:
100
99.1
99.1
95.9
N.A.
92.2
93
N.A.
82.3
N.A.
N.A.
71
N.A.
51
45.3
N.A.
30.6
P-Site Identity:
100
100
100
100
N.A.
86.6
93.3
N.A.
66.6
N.A.
N.A.
0
N.A.
6.6
6.6
N.A.
26.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
86.6
N.A.
N.A.
20
N.A.
13.3
13.3
N.A.
53.3
Percent
Protein Identity:
25.4
25.2
N.A.
25.9
21.1
N.A.
Protein Similarity:
41.8
43.1
N.A.
42.6
34.7
N.A.
P-Site Identity:
13.3
6.6
N.A.
6.6
13.3
N.A.
P-Site Similarity:
26.6
13.3
N.A.
20
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
0
0
47
27
0
0
0
0
0
7
0
% A
% Cys:
7
0
0
0
0
0
7
0
7
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
47
0
7
7
20
14
0
0
0
14
0
% D
% Glu:
0
54
0
0
7
7
14
0
0
0
14
0
7
0
0
% E
% Phe:
0
0
54
14
0
0
0
0
0
0
54
0
14
20
7
% F
% Gly:
0
0
7
40
0
0
0
0
0
7
7
14
0
0
7
% G
% His:
0
0
0
0
0
0
7
0
0
0
0
7
14
0
0
% H
% Ile:
0
7
7
0
0
7
0
7
0
20
14
14
0
0
0
% I
% Lys:
7
7
7
0
7
0
0
0
14
0
0
7
0
0
54
% K
% Leu:
47
0
0
0
0
0
0
0
0
40
0
0
0
7
14
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
7
0
0
0
7
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
14
60
0
7
0
0
0
0
0
0
0
% P
% Gln:
0
7
0
0
0
0
0
0
0
0
0
7
0
7
0
% Q
% Arg:
0
7
0
0
0
0
0
0
0
0
0
47
0
0
7
% R
% Ser:
14
0
0
0
7
7
7
40
54
0
0
7
0
0
0
% S
% Thr:
7
14
14
14
14
7
14
0
0
7
0
0
0
0
7
% T
% Val:
7
0
0
7
0
7
0
7
0
14
7
0
7
7
0
% V
% Trp:
0
0
0
0
0
7
0
7
0
0
0
0
54
0
0
% W
% Tyr:
0
0
7
14
0
0
0
0
0
0
7
0
7
40
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _