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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE12
All Species:
25.45
Human Site:
S219
Identified Species:
40
UniProt:
Q6L8Q7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6L8Q7
NP_808881.3
609
67352
S219
V
P
S
S
L
S
P
S
S
P
S
S
S
W
T
Chimpanzee
Pan troglodytes
XP_517033
609
67371
S219
V
P
S
S
L
S
P
S
S
P
S
S
S
W
T
Rhesus Macaque
Macaca mulatta
XP_001099328
609
67247
S219
V
P
S
S
L
S
S
S
S
P
S
S
S
W
T
Dog
Lupus familis
XP_541830
616
67598
S226
G
P
S
S
L
S
P
S
S
P
S
P
S
W
T
Cat
Felis silvestris
Mouse
Mus musculus
Q3TIU4
608
67495
S218
G
P
A
S
S
S
H
S
S
Q
P
S
A
W
I
Rat
Rattus norvegicus
Q6AXQ5
608
67158
S218
G
L
A
S
S
S
H
S
L
Q
S
S
A
W
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511095
639
68679
S247
S
S
T
I
S
S
A
S
A
A
G
P
G
W
V
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001038753
591
65883
I195
E
S
S
A
S
A
Y
I
T
G
D
A
E
C
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_723735
564
64146
N194
K
F
V
V
T
P
G
N
A
L
G
M
T
G
P
Honey Bee
Apis mellifera
XP_001121328
441
50969
Y71
S
K
I
E
I
P
I
Y
L
L
V
G
F
P
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784408
1354
152949
K952
E
S
S
N
D
A
T
K
T
E
H
D
L
D
G
Poplar Tree
Populus trichocarpa
XP_002323345
603
66902
S216
H
S
N
T
L
L
T
S
R
V
I
P
A
P
S
Maize
Zea mays
NP_001146094
605
67010
S219
P
S
T
S
I
M
T
S
R
V
I
P
A
P
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F8
603
67035
S214
H
P
S
T
I
L
T
S
R
V
I
P
A
P
S
Baker's Yeast
Sacchar. cerevisiae
P31384
837
94681
N424
T
L
P
W
E
F
G
N
L
C
N
L
Q
F
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.8
92.3
N.A.
88.3
89.8
N.A.
74.3
N.A.
N.A.
54.6
N.A.
33.9
29.3
N.A.
20.3
Protein Similarity:
100
99.1
99.1
95.9
N.A.
92.2
93
N.A.
82.3
N.A.
N.A.
71
N.A.
51
45.3
N.A.
30.6
P-Site Identity:
100
100
93.3
86.6
N.A.
46.6
40
N.A.
20
N.A.
N.A.
6.6
N.A.
0
0
N.A.
6.6
P-Site Similarity:
100
100
93.3
86.6
N.A.
60
53.3
N.A.
33.3
N.A.
N.A.
33.3
N.A.
20
6.6
N.A.
26.6
Percent
Protein Identity:
25.4
25.2
N.A.
25.9
21.1
N.A.
Protein Similarity:
41.8
43.1
N.A.
42.6
34.7
N.A.
P-Site Identity:
13.3
20
N.A.
20
0
N.A.
P-Site Similarity:
40
40
N.A.
46.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
14
7
0
14
7
0
14
7
0
7
34
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% C
% Asp:
0
0
0
0
7
0
0
0
0
0
7
7
0
7
0
% D
% Glu:
14
0
0
7
7
0
0
0
0
7
0
0
7
0
0
% E
% Phe:
0
7
0
0
0
7
0
0
0
0
0
0
7
7
0
% F
% Gly:
20
0
0
0
0
0
14
0
0
7
14
7
7
7
7
% G
% His:
14
0
0
0
0
0
14
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
7
7
20
0
7
7
0
0
20
0
0
0
20
% I
% Lys:
7
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% K
% Leu:
0
14
0
0
34
14
0
0
20
14
0
7
7
0
7
% L
% Met:
0
0
0
0
0
7
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
7
7
0
0
0
14
0
0
7
0
0
0
0
% N
% Pro:
7
40
7
0
0
14
20
0
0
27
7
34
0
27
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
14
0
0
7
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
20
0
0
0
0
0
0
% R
% Ser:
14
34
47
47
27
47
7
67
34
0
34
34
27
0
14
% S
% Thr:
7
0
14
14
7
0
27
0
14
0
0
0
7
0
34
% T
% Val:
20
0
7
7
0
0
0
0
0
20
7
0
0
0
7
% V
% Trp:
0
0
0
7
0
0
0
0
0
0
0
0
0
47
7
% W
% Tyr:
0
0
0
0
0
0
7
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _