Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE12 All Species: 14.24
Human Site: S223 Identified Species: 22.38
UniProt: Q6L8Q7 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6L8Q7 NP_808881.3 609 67352 S223 L S P S S P S S S W T E T D V
Chimpanzee Pan troglodytes XP_517033 609 67371 S223 L S P S S P S S S W T E T D V
Rhesus Macaque Macaca mulatta XP_001099328 609 67247 S223 L S S S S P S S S W T E T E V
Dog Lupus familis XP_541830 616 67598 P230 L S P S S P S P S W T E T G V
Cat Felis silvestris
Mouse Mus musculus Q3TIU4 608 67495 S222 S S H S S Q P S A W I E T G V
Rat Rattus norvegicus Q6AXQ5 608 67158 S222 S S H S L Q S S A W I E T G V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511095 639 68679 P251 S S A S A A G P G W V E T G V
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038753 591 65883 A199 S A Y I T G D A E C W R E A G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_723735 564 64146 M198 T P G N A L G M T G P V V E K
Honey Bee Apis mellifera XP_001121328 441 50969 G75 I P I Y L L V G F P I Y P S K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784408 1354 152949 D956 D A T K T E H D L D G L E V G
Poplar Tree Populus trichocarpa XP_002323345 603 66902 P220 L L T S R V I P A P S P T P R
Maize Zea mays NP_001146094 605 67010 P223 I M T S R V I P A P T P T P R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M2F8 603 67035 P218 I L T S R V I P A P S P S P R
Baker's Yeast Sacchar. cerevisiae P31384 837 94681 L428 E F G N L C N L Q F L G V E G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 98.8 92.3 N.A. 88.3 89.8 N.A. 74.3 N.A. N.A. 54.6 N.A. 33.9 29.3 N.A. 20.3
Protein Similarity: 100 99.1 99.1 95.9 N.A. 92.2 93 N.A. 82.3 N.A. N.A. 71 N.A. 51 45.3 N.A. 30.6
P-Site Identity: 100 100 86.6 86.6 N.A. 53.3 53.3 N.A. 40 N.A. N.A. 0 N.A. 0 0 N.A. 0
P-Site Similarity: 100 100 93.3 86.6 N.A. 60 60 N.A. 46.6 N.A. N.A. 20 N.A. 26.6 6.6 N.A. 13.3
Percent
Protein Identity: 25.4 25.2 N.A. 25.9 21.1 N.A.
Protein Similarity: 41.8 43.1 N.A. 42.6 34.7 N.A.
P-Site Identity: 20 20 N.A. 6.6 0 N.A.
P-Site Similarity: 33.3 33.3 N.A. 33.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 7 0 14 7 0 7 34 0 0 0 0 7 0 % A
% Cys: 0 0 0 0 0 7 0 0 0 7 0 0 0 0 0 % C
% Asp: 7 0 0 0 0 0 7 7 0 7 0 0 0 14 0 % D
% Glu: 7 0 0 0 0 7 0 0 7 0 0 47 14 20 0 % E
% Phe: 0 7 0 0 0 0 0 0 7 7 0 0 0 0 0 % F
% Gly: 0 0 14 0 0 7 14 7 7 7 7 7 0 27 20 % G
% His: 0 0 14 0 0 0 7 0 0 0 0 0 0 0 0 % H
% Ile: 20 0 7 7 0 0 20 0 0 0 20 0 0 0 0 % I
% Lys: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 14 % K
% Leu: 34 14 0 0 20 14 0 7 7 0 7 7 0 0 0 % L
% Met: 0 7 0 0 0 0 0 7 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 14 0 0 7 0 0 0 0 0 0 0 0 % N
% Pro: 0 14 20 0 0 27 7 34 0 27 7 20 7 20 0 % P
% Gln: 0 0 0 0 0 14 0 0 7 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 20 0 0 0 0 0 0 7 0 0 20 % R
% Ser: 27 47 7 67 34 0 34 34 27 0 14 0 7 7 0 % S
% Thr: 7 0 27 0 14 0 0 0 7 0 34 0 60 0 0 % T
% Val: 0 0 0 0 0 20 7 0 0 0 7 7 14 7 47 % V
% Trp: 0 0 0 0 0 0 0 0 0 47 7 0 0 0 0 % W
% Tyr: 0 0 7 7 0 0 0 0 0 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _