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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE12
All Species:
18.18
Human Site:
S392
Identified Species:
28.57
UniProt:
Q6L8Q7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.5
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6L8Q7
NP_808881.3
609
67352
S392
F
Y
R
K
S
K
F
S
L
L
S
Q
H
D
I
Chimpanzee
Pan troglodytes
XP_517033
609
67371
S392
F
Y
R
K
S
K
F
S
L
L
S
Q
H
D
I
Rhesus Macaque
Macaca mulatta
XP_001099328
609
67247
S392
F
Y
R
K
S
K
F
S
L
L
S
Q
H
D
I
Dog
Lupus familis
XP_541830
616
67598
S399
F
Y
R
K
T
K
F
S
L
L
S
Q
H
D
I
Cat
Felis silvestris
Mouse
Mus musculus
Q3TIU4
608
67495
R391
F
Y
R
K
S
K
F
R
L
L
S
Q
H
D
I
Rat
Rattus norvegicus
Q6AXQ5
608
67158
R391
F
Y
R
K
S
K
F
R
L
L
S
Q
H
D
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511095
639
68679
S422
F
Y
R
R
A
K
F
S
L
L
S
R
H
D
I
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001038753
591
65883
K370
Y
F
R
R
S
K
L
K
L
V
E
Q
Y
D
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_723735
564
64146
F357
N
I
P
A
L
P
V
F
E
S
L
W
N
K
I
Honey Bee
Apis mellifera
XP_001121328
441
50969
N234
S
V
I
S
Q
G
I
N
N
L
N
E
F
N
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784408
1354
152949
R1128
F
Y
R
E
D
R
F
R
L
L
E
Q
Y
D
I
Poplar Tree
Populus trichocarpa
XP_002323345
603
66902
R381
A
L
V
P
S
A
Q
R
K
T
A
L
N
R
L
Maize
Zea mays
NP_001146094
605
67010
K383
A
I
I
P
A
A
Q
K
R
V
A
L
S
R
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F8
603
67035
Q378
D
A
L
I
P
Q
A
Q
K
R
T
A
L
N
R
Baker's Yeast
Sacchar. cerevisiae
P31384
837
94681
K609
F
F
K
R
D
Q
F
K
L
I
T
K
D
A
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.8
92.3
N.A.
88.3
89.8
N.A.
74.3
N.A.
N.A.
54.6
N.A.
33.9
29.3
N.A.
20.3
Protein Similarity:
100
99.1
99.1
95.9
N.A.
92.2
93
N.A.
82.3
N.A.
N.A.
71
N.A.
51
45.3
N.A.
30.6
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
80
N.A.
N.A.
40
N.A.
6.6
6.6
N.A.
60
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
N.A.
N.A.
80
N.A.
13.3
33.3
N.A.
80
Percent
Protein Identity:
25.4
25.2
N.A.
25.9
21.1
N.A.
Protein Similarity:
41.8
43.1
N.A.
42.6
34.7
N.A.
P-Site Identity:
6.6
0
N.A.
0
20
N.A.
P-Site Similarity:
26.6
26.6
N.A.
20
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
0
7
14
14
7
0
0
0
14
7
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
14
0
0
0
0
0
0
0
7
60
0
% D
% Glu:
0
0
0
7
0
0
0
0
7
0
14
7
0
0
0
% E
% Phe:
60
14
0
0
0
0
60
7
0
0
0
0
7
0
0
% F
% Gly:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
47
0
0
% H
% Ile:
0
14
14
7
0
0
7
0
0
7
0
0
0
0
60
% I
% Lys:
0
0
7
40
0
54
0
20
14
0
0
7
0
7
0
% K
% Leu:
0
7
7
0
7
0
7
0
67
60
7
14
7
0
14
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
7
0
0
0
0
0
0
7
7
0
7
0
14
14
0
% N
% Pro:
0
0
7
14
7
7
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
7
14
14
7
0
0
0
54
0
0
0
% Q
% Arg:
0
0
60
20
0
7
0
27
7
7
0
7
0
14
7
% R
% Ser:
7
0
0
7
47
0
0
34
0
7
47
0
7
0
0
% S
% Thr:
0
0
0
0
7
0
0
0
0
7
14
0
0
0
7
% T
% Val:
0
7
7
0
0
0
7
0
0
14
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
7
54
0
0
0
0
0
0
0
0
0
0
14
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _