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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE12
All Species:
27.27
Human Site:
S446
Identified Species:
42.86
UniProt:
Q6L8Q7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6L8Q7
NP_808881.3
609
67352
S446
V
L
Q
S
T
K
D
S
S
K
R
I
C
V
A
Chimpanzee
Pan troglodytes
XP_517033
609
67371
S446
V
L
Q
S
T
K
D
S
S
K
R
I
C
V
A
Rhesus Macaque
Macaca mulatta
XP_001099328
609
67247
S446
V
L
Q
S
T
K
D
S
S
K
R
I
C
V
A
Dog
Lupus familis
XP_541830
616
67598
S453
V
L
Q
S
T
K
D
S
S
K
R
L
C
V
A
Cat
Felis silvestris
Mouse
Mus musculus
Q3TIU4
608
67495
S445
V
L
Q
S
T
T
D
S
S
K
K
I
C
V
A
Rat
Rattus norvegicus
Q6AXQ5
608
67158
S445
V
L
Q
S
T
T
D
S
S
K
K
I
C
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511095
639
68679
S476
I
L
Q
S
T
K
D
S
S
K
K
I
C
V
A
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001038753
591
65883
P424
V
L
Q
S
L
C
D
P
S
R
I
L
C
V
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_723735
564
64146
I411
F
H
P
D
A
D
H
I
R
L
L
Q
M
G
F
Honey Bee
Apis mellifera
XP_001121328
441
50969
K288
T
H
L
Y
F
R
L
K
A
N
H
I
R
L
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784408
1354
152949
P1182
V
L
E
D
C
H
D
P
R
R
R
I
C
V
A
Poplar Tree
Populus trichocarpa
XP_002323345
603
66902
L435
Q
D
L
K
D
V
K
L
W
Q
V
L
T
L
L
Maize
Zea mays
NP_001146094
605
67010
L437
Q
D
L
K
D
V
K
L
W
E
V
H
T
L
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F8
603
67035
K432
Q
Q
D
L
K
D
V
K
L
W
Q
V
H
T
L
Baker's Yeast
Sacchar. cerevisiae
P31384
837
94681
T663
G
D
T
I
W
A
V
T
T
H
L
H
W
D
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.8
92.3
N.A.
88.3
89.8
N.A.
74.3
N.A.
N.A.
54.6
N.A.
33.9
29.3
N.A.
20.3
Protein Similarity:
100
99.1
99.1
95.9
N.A.
92.2
93
N.A.
82.3
N.A.
N.A.
71
N.A.
51
45.3
N.A.
30.6
P-Site Identity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
86.6
N.A.
N.A.
53.3
N.A.
0
6.6
N.A.
53.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
N.A.
N.A.
66.6
N.A.
0
26.6
N.A.
66.6
Percent
Protein Identity:
25.4
25.2
N.A.
25.9
21.1
N.A.
Protein Similarity:
41.8
43.1
N.A.
42.6
34.7
N.A.
P-Site Identity:
0
0
N.A.
0
0
N.A.
P-Site Similarity:
20
13.3
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
7
0
0
7
0
0
0
0
0
54
% A
% Cys:
0
0
0
0
7
7
0
0
0
0
0
0
60
0
0
% C
% Asp:
0
20
7
14
14
14
60
0
0
0
0
0
0
7
0
% D
% Glu:
0
0
7
0
0
0
0
0
0
7
0
0
0
0
0
% E
% Phe:
7
0
0
0
7
0
0
0
0
0
0
0
0
0
7
% F
% Gly:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
7
% G
% His:
0
14
0
0
0
7
7
0
0
7
7
14
7
0
0
% H
% Ile:
7
0
0
7
0
0
0
7
0
0
7
54
0
0
0
% I
% Lys:
0
0
0
14
7
34
14
14
0
47
20
0
0
0
0
% K
% Leu:
0
60
20
7
7
0
7
14
7
7
14
20
0
20
27
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% N
% Pro:
0
0
7
0
0
0
0
14
0
0
0
0
0
0
7
% P
% Gln:
20
7
54
0
0
0
0
0
0
7
7
7
0
0
0
% Q
% Arg:
0
0
0
0
0
7
0
0
14
14
34
0
7
0
0
% R
% Ser:
0
0
0
54
0
0
0
47
54
0
0
0
0
0
0
% S
% Thr:
7
0
7
0
47
14
0
7
7
0
0
0
14
7
0
% T
% Val:
54
0
0
0
0
14
14
0
0
0
14
7
0
60
0
% V
% Trp:
0
0
0
0
7
0
0
0
14
7
0
0
7
0
0
% W
% Tyr:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _