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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE12
All Species:
31.52
Human Site:
S523
Identified Species:
49.52
UniProt:
Q6L8Q7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6L8Q7
NP_808881.3
609
67352
S523
E
D
H
E
D
W
A
S
N
G
E
E
E
R
C
Chimpanzee
Pan troglodytes
XP_517033
609
67371
S523
E
D
H
E
D
W
A
S
N
G
E
E
E
R
C
Rhesus Macaque
Macaca mulatta
XP_001099328
609
67247
S523
E
D
H
E
D
W
A
S
N
G
E
E
E
R
C
Dog
Lupus familis
XP_541830
616
67598
S530
E
D
H
E
D
W
A
S
N
G
E
E
E
R
C
Cat
Felis silvestris
Mouse
Mus musculus
Q3TIU4
608
67495
S522
E
D
H
E
D
W
A
S
N
G
E
E
E
R
C
Rat
Rattus norvegicus
Q6AXQ5
608
67158
S522
E
D
H
E
D
W
A
S
N
G
E
E
E
R
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511095
639
68679
S553
E
D
H
E
D
W
A
S
N
G
E
E
E
R
C
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001038753
591
65883
S501
E
D
H
E
D
W
G
S
G
G
P
E
E
Q
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_723735
564
64146
E486
E
Q
A
V
S
N
V
E
L
A
Q
P
F
K
M
Honey Bee
Apis mellifera
XP_001121328
441
50969
I363
S
Q
E
H
V
Q
N
I
S
I
K
H
D
L
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784408
1354
152949
G1266
N
N
V
Q
W
Y
C
G
G
K
E
E
F
C
G
Poplar Tree
Populus trichocarpa
XP_002323345
603
66902
S512
P
L
V
S
A
Y
S
S
F
A
R
V
G
V
G
Maize
Zea mays
NP_001146094
605
67010
A514
P
L
V
S
A
Y
S
A
F
A
R
M
V
G
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F8
603
67035
F511
L
V
S
A
Y
S
S
F
V
R
K
G
I
M
G
Baker's Yeast
Sacchar. cerevisiae
P31384
837
94681
F742
Q
E
G
N
G
R
D
F
G
Y
M
S
E
K
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.8
92.3
N.A.
88.3
89.8
N.A.
74.3
N.A.
N.A.
54.6
N.A.
33.9
29.3
N.A.
20.3
Protein Similarity:
100
99.1
99.1
95.9
N.A.
92.2
93
N.A.
82.3
N.A.
N.A.
71
N.A.
51
45.3
N.A.
30.6
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
N.A.
N.A.
66.6
N.A.
6.6
0
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
N.A.
N.A.
73.3
N.A.
20
20
N.A.
33.3
Percent
Protein Identity:
25.4
25.2
N.A.
25.9
21.1
N.A.
Protein Similarity:
41.8
43.1
N.A.
42.6
34.7
N.A.
P-Site Identity:
6.6
0
N.A.
0
6.6
N.A.
P-Site Similarity:
20
20
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
14
0
47
7
0
20
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
0
0
0
7
47
% C
% Asp:
0
54
0
0
54
0
7
0
0
0
0
0
7
0
0
% D
% Glu:
60
7
7
54
0
0
0
7
0
0
54
60
60
0
0
% E
% Phe:
0
0
0
0
0
0
0
14
14
0
0
0
14
0
0
% F
% Gly:
0
0
7
0
7
0
7
7
20
54
0
7
7
7
20
% G
% His:
0
0
54
7
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
7
0
7
0
0
7
0
7
% I
% Lys:
0
0
0
0
0
0
0
0
0
7
14
0
0
14
0
% K
% Leu:
7
14
0
0
0
0
0
0
7
0
0
0
0
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
7
7
0
7
7
% M
% Asn:
7
7
0
7
0
7
7
0
47
0
0
0
0
0
14
% N
% Pro:
14
0
0
0
0
0
0
0
0
0
7
7
0
0
0
% P
% Gln:
7
14
0
7
0
7
0
0
0
0
7
0
0
7
0
% Q
% Arg:
0
0
0
0
0
7
0
0
0
7
14
0
0
47
0
% R
% Ser:
7
0
7
14
7
7
20
60
7
0
0
7
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
7
20
7
7
0
7
0
7
0
0
7
7
7
7
% V
% Trp:
0
0
0
0
7
54
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
20
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _