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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE12
All Species:
26.36
Human Site:
S59
Identified Species:
41.43
UniProt:
Q6L8Q7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6L8Q7
NP_808881.3
609
67352
S59
S
F
A
L
A
D
G
S
H
K
N
M
Q
R
D
Chimpanzee
Pan troglodytes
XP_517033
609
67371
S59
S
F
A
L
A
D
G
S
H
K
N
M
Q
R
D
Rhesus Macaque
Macaca mulatta
XP_001099328
609
67247
S59
S
F
A
L
A
D
G
S
H
K
N
M
Q
R
D
Dog
Lupus familis
XP_541830
616
67598
S62
S
F
A
L
A
D
G
S
H
K
N
M
Q
R
D
Cat
Felis silvestris
Mouse
Mus musculus
Q3TIU4
608
67495
S58
S
F
A
L
A
D
G
S
H
K
N
M
Q
R
D
Rat
Rattus norvegicus
Q6AXQ5
608
67158
S58
S
F
A
L
A
D
G
S
H
K
N
M
Q
R
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511095
639
68679
R60
S
F
S
L
A
D
G
R
Q
K
H
M
Q
R
S
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001038753
591
65883
L51
C
V
E
S
E
S
K
L
T
I
S
F
S
L
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_723735
564
64146
Q50
D
A
I
L
A
R
I
Q
S
N
I
I
G
R
L
Honey Bee
Apis mellifera
XP_001121328
441
50969
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784408
1354
152949
I279
V
H
G
M
D
D
E
I
D
D
N
D
K
S
V
Poplar Tree
Populus trichocarpa
XP_002323345
603
66902
S66
D
R
K
V
A
I
C
S
V
H
P
S
E
Q
A
Maize
Zea mays
NP_001146094
605
67010
S58
Y
R
W
Y
R
I
Q
S
D
R
K
V
P
I
C
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F8
603
67035
T63
V
Q
S
D
K
K
V
T
I
C
S
V
H
P
T
Baker's Yeast
Sacchar. cerevisiae
P31384
837
94681
P224
A
A
P
P
A
L
Q
P
T
D
F
Q
Q
S
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.8
92.3
N.A.
88.3
89.8
N.A.
74.3
N.A.
N.A.
54.6
N.A.
33.9
29.3
N.A.
20.3
Protein Similarity:
100
99.1
99.1
95.9
N.A.
92.2
93
N.A.
82.3
N.A.
N.A.
71
N.A.
51
45.3
N.A.
30.6
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
66.6
N.A.
N.A.
0
N.A.
20
0
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
80
N.A.
N.A.
13.3
N.A.
26.6
0
N.A.
26.6
Percent
Protein Identity:
25.4
25.2
N.A.
25.9
21.1
N.A.
Protein Similarity:
41.8
43.1
N.A.
42.6
34.7
N.A.
P-Site Identity:
13.3
6.6
N.A.
0
13.3
N.A.
P-Site Similarity:
33.3
20
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
14
40
0
67
0
0
0
0
0
0
0
0
0
7
% A
% Cys:
7
0
0
0
0
0
7
0
0
7
0
0
0
0
7
% C
% Asp:
14
0
0
7
7
54
0
0
14
14
0
7
0
0
40
% D
% Glu:
0
0
7
0
7
0
7
0
0
0
0
0
7
0
0
% E
% Phe:
0
47
0
0
0
0
0
0
0
0
7
7
0
0
0
% F
% Gly:
0
0
7
0
0
0
47
0
0
0
0
0
7
0
0
% G
% His:
0
7
0
0
0
0
0
0
40
7
7
0
7
0
7
% H
% Ile:
0
0
7
0
0
14
7
7
7
7
7
7
0
7
0
% I
% Lys:
0
0
7
0
7
7
7
0
0
47
7
0
7
0
0
% K
% Leu:
0
0
0
54
0
7
0
7
0
0
0
0
0
7
7
% L
% Met:
0
0
0
7
0
0
0
0
0
0
0
47
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
7
47
0
0
0
7
% N
% Pro:
0
0
7
7
0
0
0
7
0
0
7
0
7
7
0
% P
% Gln:
0
7
0
0
0
0
14
7
7
0
0
7
54
7
0
% Q
% Arg:
0
14
0
0
7
7
0
7
0
7
0
0
0
54
0
% R
% Ser:
47
0
14
7
0
7
0
54
7
0
14
7
7
14
7
% S
% Thr:
0
0
0
0
0
0
0
7
14
0
0
0
0
0
7
% T
% Val:
14
7
0
7
0
0
7
0
7
0
0
14
0
0
7
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _