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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE12 All Species: 20.3
Human Site: T16 Identified Species: 31.9
UniProt: Q6L8Q7 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6L8Q7 NP_808881.3 609 67352 T16 A A L R V I R T A V E K L S R
Chimpanzee Pan troglodytes XP_517033 609 67371 T16 A A L R V I R T A V E K L S R
Rhesus Macaque Macaca mulatta XP_001099328 609 67247 T16 A A L R V I R T A L E K L S P
Dog Lupus familis XP_541830 616 67598 E19 R G V R T A V E R H T R A E A
Cat Felis silvestris
Mouse Mus musculus Q3TIU4 608 67495 S15 S A L R G V R S V V E R R S R
Rat Rattus norvegicus Q6AXQ5 608 67158 S15 A A L R G V R S V V E Q R S P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511095 639 68679 A17 R R R G A A A A A G A E V A A
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038753 591 65883 S8 M W S R L S F S T R S F F F R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_723735 564 64146
Honey Bee Apis mellifera XP_001121328 441 50969
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784408 1354 152949 T236 E D V H N V V T F L E K V A N
Poplar Tree Populus trichocarpa XP_002323345 603 66902 Y23 V G C E L T P Y V L L R R P D
Maize Zea mays NP_001146094 605 67010 I15 H L P S E I P I V G C E I T P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M2F8 603 67035 L20 I P I V G C E L T P Y V L V R
Baker's Yeast Sacchar. cerevisiae P31384 837 94681 N181 P N I Y A R Q N A M K K Y L A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 98.8 92.3 N.A. 88.3 89.8 N.A. 74.3 N.A. N.A. 54.6 N.A. 33.9 29.3 N.A. 20.3
Protein Similarity: 100 99.1 99.1 95.9 N.A. 92.2 93 N.A. 82.3 N.A. N.A. 71 N.A. 51 45.3 N.A. 30.6
P-Site Identity: 100 100 86.6 6.6 N.A. 53.3 53.3 N.A. 6.6 N.A. N.A. 13.3 N.A. 0 0 N.A. 20
P-Site Similarity: 100 100 93.3 20 N.A. 80 73.3 N.A. 26.6 N.A. N.A. 26.6 N.A. 0 0 N.A. 53.3
Percent
Protein Identity: 25.4 25.2 N.A. 25.9 21.1 N.A.
Protein Similarity: 41.8 43.1 N.A. 42.6 34.7 N.A.
P-Site Identity: 0 6.6 N.A. 13.3 13.3 N.A.
P-Site Similarity: 20 26.6 N.A. 20 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 27 34 0 0 14 14 7 7 34 0 7 0 7 14 20 % A
% Cys: 0 0 7 0 0 7 0 0 0 0 7 0 0 0 0 % C
% Asp: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 7 % D
% Glu: 7 0 0 7 7 0 7 7 0 0 40 14 0 7 0 % E
% Phe: 0 0 0 0 0 0 7 0 7 0 0 7 7 7 0 % F
% Gly: 0 14 0 7 20 0 0 0 0 14 0 0 0 0 0 % G
% His: 7 0 0 7 0 0 0 0 0 7 0 0 0 0 0 % H
% Ile: 7 0 14 0 0 27 0 7 0 0 0 0 7 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 7 34 0 0 0 % K
% Leu: 0 7 34 0 14 0 0 7 0 20 7 0 27 7 0 % L
% Met: 7 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % M
% Asn: 0 7 0 0 7 0 0 7 0 0 0 0 0 0 7 % N
% Pro: 7 7 7 0 0 0 14 0 0 7 0 0 0 7 20 % P
% Gln: 0 0 0 0 0 0 7 0 0 0 0 7 0 0 0 % Q
% Arg: 14 7 7 47 0 7 34 0 7 7 0 20 20 0 34 % R
% Ser: 7 0 7 7 0 7 0 20 0 0 7 0 0 34 0 % S
% Thr: 0 0 0 0 7 7 0 27 14 0 7 0 0 7 0 % T
% Val: 7 0 14 7 20 20 14 0 27 27 0 7 14 7 0 % V
% Trp: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 7 0 0 7 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _