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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE12
All Species:
16.67
Human Site:
T226
Identified Species:
26.19
UniProt:
Q6L8Q7
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6L8Q7
NP_808881.3
609
67352
T226
S
S
P
S
S
S
W
T
E
T
D
V
E
E
R
Chimpanzee
Pan troglodytes
XP_517033
609
67371
T226
S
S
P
S
S
S
W
T
E
T
D
V
E
E
R
Rhesus Macaque
Macaca mulatta
XP_001099328
609
67247
T226
S
S
P
S
S
S
W
T
E
T
E
V
E
E
R
Dog
Lupus familis
XP_541830
616
67598
T233
S
S
P
S
P
S
W
T
E
T
G
V
N
E
R
Cat
Felis silvestris
Mouse
Mus musculus
Q3TIU4
608
67495
I225
S
S
Q
P
S
A
W
I
E
T
G
V
D
E
R
Rat
Rattus norvegicus
Q6AXQ5
608
67158
I225
S
L
Q
S
S
A
W
I
E
T
G
V
D
E
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511095
639
68679
V254
S
A
A
G
P
G
W
V
E
T
G
V
S
E
L
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001038753
591
65883
W202
I
T
G
D
A
E
C
W
R
E
A
G
S
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_723735
564
64146
P201
N
A
L
G
M
T
G
P
V
V
E
K
I
T
N
Honey Bee
Apis mellifera
XP_001121328
441
50969
I78
Y
L
L
V
G
F
P
I
Y
P
S
K
F
E
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784408
1354
152949
G959
K
T
E
H
D
L
D
G
L
E
V
G
Q
R
K
Poplar Tree
Populus trichocarpa
XP_002323345
603
66902
S223
S
R
V
I
P
A
P
S
P
T
P
R
R
L
I
Maize
Zea mays
NP_001146094
605
67010
T226
S
R
V
I
P
A
P
T
P
T
P
R
R
L
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F8
603
67035
S221
S
R
V
I
P
A
P
S
P
S
P
R
K
L
I
Baker's Yeast
Sacchar. cerevisiae
P31384
837
94681
L431
N
L
C
N
L
Q
F
L
G
V
E
G
N
P
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.8
92.3
N.A.
88.3
89.8
N.A.
74.3
N.A.
N.A.
54.6
N.A.
33.9
29.3
N.A.
20.3
Protein Similarity:
100
99.1
99.1
95.9
N.A.
92.2
93
N.A.
82.3
N.A.
N.A.
71
N.A.
51
45.3
N.A.
30.6
P-Site Identity:
100
100
93.3
80
N.A.
60
60
N.A.
40
N.A.
N.A.
13.3
N.A.
0
6.6
N.A.
0
P-Site Similarity:
100
100
100
80
N.A.
73.3
73.3
N.A.
46.6
N.A.
N.A.
26.6
N.A.
26.6
6.6
N.A.
20
Percent
Protein Identity:
25.4
25.2
N.A.
25.9
21.1
N.A.
Protein Similarity:
41.8
43.1
N.A.
42.6
34.7
N.A.
P-Site Identity:
13.3
20
N.A.
6.6
0
N.A.
P-Site Similarity:
26.6
26.6
N.A.
33.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
14
7
0
7
34
0
0
0
0
7
0
0
0
0
% A
% Cys:
0
0
7
0
0
0
7
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
7
0
7
0
0
0
14
0
14
0
0
% D
% Glu:
0
0
7
0
0
7
0
0
47
14
20
0
20
60
0
% E
% Phe:
0
0
0
0
0
7
7
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
7
14
7
7
7
7
7
0
27
20
0
0
7
% G
% His:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
20
0
0
0
20
0
0
0
0
7
0
20
% I
% Lys:
7
0
0
0
0
0
0
0
0
0
0
14
7
0
7
% K
% Leu:
0
20
14
0
7
7
0
7
7
0
0
0
0
20
14
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
14
0
0
7
0
0
0
0
0
0
0
0
14
0
7
% N
% Pro:
0
0
27
7
34
0
27
7
20
7
20
0
0
7
0
% P
% Gln:
0
0
14
0
0
7
0
0
0
0
0
0
7
0
0
% Q
% Arg:
0
20
0
0
0
0
0
0
7
0
0
20
14
7
47
% R
% Ser:
67
34
0
34
34
27
0
14
0
7
7
0
14
0
0
% S
% Thr:
0
14
0
0
0
7
0
34
0
60
0
0
0
7
0
% T
% Val:
0
0
20
7
0
0
0
7
7
14
7
47
0
0
0
% V
% Trp:
0
0
0
0
0
0
47
7
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _