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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE12
All Species:
30.61
Human Site:
T535
Identified Species:
48.1
UniProt:
Q6L8Q7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6L8Q7
NP_808881.3
609
67352
T535
E
R
C
N
M
S
L
T
H
F
F
K
L
K
S
Chimpanzee
Pan troglodytes
XP_517033
609
67371
T535
E
R
C
N
M
S
L
T
H
F
F
K
L
K
S
Rhesus Macaque
Macaca mulatta
XP_001099328
609
67247
T535
E
R
C
N
M
S
L
T
H
F
F
K
L
K
S
Dog
Lupus familis
XP_541830
616
67598
S542
E
R
C
N
M
S
L
S
H
F
F
K
L
K
S
Cat
Felis silvestris
Mouse
Mus musculus
Q3TIU4
608
67495
S534
E
R
C
S
M
P
L
S
H
C
F
K
L
K
S
Rat
Rattus norvegicus
Q6AXQ5
608
67158
T534
E
R
C
G
M
S
L
T
H
C
F
K
L
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511095
639
68679
T565
E
R
C
N
M
A
L
T
H
P
F
K
L
K
S
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001038753
591
65883
T513
E
Q
I
R
L
G
L
T
N
P
F
Q
L
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_723735
564
64146
G498
F
K
M
A
S
A
Y
G
A
P
E
Y
T
H
Y
Honey Bee
Apis mellifera
XP_001121328
441
50969
C375
D
L
N
L
A
S
A
C
G
I
P
E
Y
T
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784408
1354
152949
S1278
F
C
G
G
M
T
L
S
H
S
V
D
F
T
N
Poplar Tree
Populus trichocarpa
XP_002323345
603
66902
Q524
G
V
G
L
G
S
D
Q
Q
R
R
R
M
D
A
Maize
Zea mays
NP_001146094
605
67010
E526
V
G
V
G
Y
D
L
E
H
Q
R
R
T
D
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F8
603
67035
Q523
I
M
G
L
G
L
E
Q
H
R
R
R
I
D
L
Baker's Yeast
Sacchar. cerevisiae
P31384
837
94681
L754
E
K
N
F
S
H
N
L
A
L
K
S
S
Y
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.8
92.3
N.A.
88.3
89.8
N.A.
74.3
N.A.
N.A.
54.6
N.A.
33.9
29.3
N.A.
20.3
Protein Similarity:
100
99.1
99.1
95.9
N.A.
92.2
93
N.A.
82.3
N.A.
N.A.
71
N.A.
51
45.3
N.A.
30.6
P-Site Identity:
100
100
100
93.3
N.A.
73.3
86.6
N.A.
86.6
N.A.
N.A.
40
N.A.
0
6.6
N.A.
20
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
93.3
N.A.
N.A.
66.6
N.A.
13.3
26.6
N.A.
40
Percent
Protein Identity:
25.4
25.2
N.A.
25.9
21.1
N.A.
Protein Similarity:
41.8
43.1
N.A.
42.6
34.7
N.A.
P-Site Identity:
6.6
13.3
N.A.
6.6
6.6
N.A.
P-Site Similarity:
26.6
20
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
7
14
7
0
14
0
0
0
0
0
7
% A
% Cys:
0
7
47
0
0
0
0
7
0
14
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
7
7
0
0
0
0
7
0
20
0
% D
% Glu:
60
0
0
0
0
0
7
7
0
0
7
7
0
0
0
% E
% Phe:
14
0
0
7
0
0
0
0
0
27
54
0
7
0
0
% F
% Gly:
7
7
20
20
14
7
0
7
7
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
7
0
0
67
0
0
0
0
7
0
% H
% Ile:
7
0
7
0
0
0
0
0
0
7
0
0
7
0
0
% I
% Lys:
0
14
0
0
0
0
0
0
0
0
7
47
0
47
0
% K
% Leu:
0
7
0
20
7
7
67
7
0
7
0
0
54
0
7
% L
% Met:
0
7
7
0
54
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
0
0
14
34
0
0
7
0
7
0
0
0
0
0
20
% N
% Pro:
0
0
0
0
0
7
0
0
0
20
7
0
0
0
7
% P
% Gln:
0
7
0
0
0
0
0
14
7
7
0
7
0
0
0
% Q
% Arg:
0
47
0
7
0
0
0
0
0
14
20
20
0
0
0
% R
% Ser:
0
0
0
7
14
47
0
20
0
7
0
7
7
7
54
% S
% Thr:
0
0
0
0
0
7
0
40
0
0
0
0
14
14
0
% T
% Val:
7
7
7
0
0
0
0
0
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
7
0
0
0
0
7
7
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _