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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE12
All Species:
32.42
Human Site:
Y285
Identified Species:
50.95
UniProt:
Q6L8Q7
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6L8Q7
NP_808881.3
609
67352
Y285
T
F
D
H
R
H
L
Y
T
K
K
V
T
E
D
Chimpanzee
Pan troglodytes
XP_517033
609
67371
Y285
T
F
D
H
R
H
L
Y
T
K
K
V
T
E
D
Rhesus Macaque
Macaca mulatta
XP_001099328
609
67247
Y285
T
F
D
H
R
H
L
Y
T
K
K
V
T
E
D
Dog
Lupus familis
XP_541830
616
67598
Y292
T
F
D
H
R
H
L
Y
T
K
K
V
T
D
N
Cat
Felis silvestris
Mouse
Mus musculus
Q3TIU4
608
67495
Y284
T
F
D
H
R
H
L
Y
T
K
K
V
T
E
D
Rat
Rattus norvegicus
Q6AXQ5
608
67158
Y284
T
F
D
H
R
H
L
Y
T
K
K
V
T
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511095
639
68679
Y313
T
F
D
Q
R
H
L
Y
T
K
K
V
A
S
D
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001038753
591
65883
Y261
T
F
D
N
R
H
I
Y
T
Q
K
L
T
D
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_723735
564
64146
F260
D
Y
A
G
S
T
L
F
S
Y
C
P
A
K
Y
Honey Bee
Apis mellifera
XP_001121328
441
50969
N137
K
N
K
L
R
N
K
N
F
R
V
T
S
Y
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784408
1354
152949
F1018
P
F
Q
K
R
H
E
F
T
K
N
R
T
S
P
Poplar Tree
Populus trichocarpa
XP_002323345
603
66902
P282
P
S
W
A
L
S
W
P
Y
R
R
Q
N
L
L
Maize
Zea mays
NP_001146094
605
67010
Y285
T
W
A
L
T
W
N
Y
R
R
Q
N
L
L
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F8
603
67035
P280
P
P
W
A
L
S
W
P
Y
R
R
Q
N
L
L
Baker's Yeast
Sacchar. cerevisiae
P31384
837
94681
Q490
Q
R
E
Y
D
S
L
Q
Q
S
T
E
H
L
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.8
92.3
N.A.
88.3
89.8
N.A.
74.3
N.A.
N.A.
54.6
N.A.
33.9
29.3
N.A.
20.3
Protein Similarity:
100
99.1
99.1
95.9
N.A.
92.2
93
N.A.
82.3
N.A.
N.A.
71
N.A.
51
45.3
N.A.
30.6
P-Site Identity:
100
100
100
86.6
N.A.
100
100
N.A.
80
N.A.
N.A.
60
N.A.
6.6
6.6
N.A.
40
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
80
N.A.
N.A.
100
N.A.
33.3
33.3
N.A.
46.6
Percent
Protein Identity:
25.4
25.2
N.A.
25.9
21.1
N.A.
Protein Similarity:
41.8
43.1
N.A.
42.6
34.7
N.A.
P-Site Identity:
0
13.3
N.A.
0
6.6
N.A.
P-Site Similarity:
13.3
33.3
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
14
14
0
0
0
0
0
0
0
0
14
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
7
0
54
0
7
0
0
0
0
0
0
0
0
14
40
% D
% Glu:
0
0
7
0
0
0
7
0
0
0
0
7
0
34
7
% E
% Phe:
0
60
0
0
0
0
0
14
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
40
0
60
0
0
0
0
0
0
7
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% I
% Lys:
7
0
7
7
0
0
7
0
0
54
54
0
0
7
0
% K
% Leu:
0
0
0
14
14
0
60
0
0
0
0
7
7
27
14
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
7
0
7
7
7
0
0
7
7
14
0
14
% N
% Pro:
20
7
0
0
0
0
0
14
0
0
0
7
0
0
7
% P
% Gln:
7
0
7
7
0
0
0
7
7
7
7
14
0
0
0
% Q
% Arg:
0
7
0
0
67
0
0
0
7
27
14
7
0
0
7
% R
% Ser:
0
7
0
0
7
20
0
0
7
7
0
0
7
14
0
% S
% Thr:
60
0
0
0
7
7
0
0
60
0
7
7
54
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
7
47
0
0
0
% V
% Trp:
0
7
14
0
0
7
14
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
7
0
0
0
60
14
7
0
0
0
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _