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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE12
All Species:
37.58
Human Site:
Y320
Identified Species:
59.05
UniProt:
Q6L8Q7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6L8Q7
NP_808881.3
609
67352
Y320
S
R
T
V
L
Y
P
Y
C
A
P
Y
A
L
E
Chimpanzee
Pan troglodytes
XP_517033
609
67371
Y320
S
R
T
V
L
Y
P
Y
C
A
P
Y
A
L
E
Rhesus Macaque
Macaca mulatta
XP_001099328
609
67247
Y320
S
R
T
V
L
Y
P
Y
C
A
P
Y
A
L
E
Dog
Lupus familis
XP_541830
616
67598
Y327
S
R
S
V
L
Y
P
Y
C
A
P
Y
A
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q3TIU4
608
67495
Y319
S
R
T
V
L
Y
P
Y
C
A
P
Y
A
L
E
Rat
Rattus norvegicus
Q6AXQ5
608
67158
Y319
S
R
T
V
L
Y
P
Y
C
A
P
Y
A
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511095
639
68679
Y348
S
R
T
V
L
Y
P
Y
C
A
P
Y
A
L
E
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001038753
591
65883
Y296
S
K
T
V
L
Y
P
Y
C
A
P
Y
A
L
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_723735
564
64146
D295
I
L
C
L
Q
E
V
D
Q
R
I
F
D
F
D
Honey Bee
Apis mellifera
XP_001121328
441
50969
D172
P
H
Y
A
L
S
M
D
Y
R
K
L
L
I
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784408
1354
152949
Y677
S
R
D
Y
L
Y
P
Y
C
S
P
V
A
L
D
Poplar Tree
Populus trichocarpa
XP_002323345
603
66902
E317
Y
E
E
F
F
A
P
E
L
D
K
H
G
Y
Q
Maize
Zea mays
NP_001146094
605
67010
L320
E
D
F
F
S
P
E
L
D
K
H
G
Y
Q
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F8
603
67035
E315
F
H
E
I
F
A
P
E
L
D
K
H
G
Y
Q
Baker's Yeast
Sacchar. cerevisiae
P31384
837
94681
Y525
A
T
P
K
M
Y
R
Y
T
P
S
W
A
L
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.8
92.3
N.A.
88.3
89.8
N.A.
74.3
N.A.
N.A.
54.6
N.A.
33.9
29.3
N.A.
20.3
Protein Similarity:
100
99.1
99.1
95.9
N.A.
92.2
93
N.A.
82.3
N.A.
N.A.
71
N.A.
51
45.3
N.A.
30.6
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
100
N.A.
N.A.
86.6
N.A.
0
6.6
N.A.
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
N.A.
N.A.
100
N.A.
20
13.3
N.A.
80
Percent
Protein Identity:
25.4
25.2
N.A.
25.9
21.1
N.A.
Protein Similarity:
41.8
43.1
N.A.
42.6
34.7
N.A.
P-Site Identity:
6.6
0
N.A.
6.6
26.6
N.A.
P-Site Similarity:
20
0
N.A.
26.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
0
14
0
0
0
54
0
0
67
0
7
% A
% Cys:
0
0
7
0
0
0
0
0
60
0
0
0
0
0
0
% C
% Asp:
0
7
7
0
0
0
0
14
7
14
0
0
7
0
14
% D
% Glu:
7
7
14
0
0
7
7
14
0
0
0
0
0
0
47
% E
% Phe:
7
0
7
14
14
0
0
0
0
0
0
7
0
7
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
7
14
0
0
% G
% His:
0
14
0
0
0
0
0
0
0
0
7
14
0
0
0
% H
% Ile:
7
0
0
7
0
0
0
0
0
0
7
0
0
7
0
% I
% Lys:
0
7
0
7
0
0
0
0
0
7
20
0
0
0
0
% K
% Leu:
0
7
0
7
67
0
0
7
14
0
0
7
7
67
7
% L
% Met:
0
0
0
0
7
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
7
0
7
0
0
7
74
0
0
7
60
0
0
0
0
% P
% Gln:
0
0
0
0
7
0
0
0
7
0
0
0
0
7
20
% Q
% Arg:
0
54
0
0
0
0
7
0
0
14
0
0
0
0
0
% R
% Ser:
60
0
7
0
7
7
0
0
0
7
7
0
0
0
7
% S
% Thr:
0
7
47
0
0
0
0
0
7
0
0
0
0
0
0
% T
% Val:
0
0
0
54
0
0
7
0
0
0
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
7
0
7
7
0
67
0
67
7
0
0
54
7
14
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _