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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE12
All Species:
15.45
Human Site:
Y402
Identified Species:
24.29
UniProt:
Q6L8Q7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6L8Q7
NP_808881.3
609
67352
Y402
S
Q
H
D
I
S
F
Y
E
A
L
E
S
D
P
Chimpanzee
Pan troglodytes
XP_517033
609
67371
Y402
S
Q
H
D
I
S
F
Y
E
A
L
E
S
D
P
Rhesus Macaque
Macaca mulatta
XP_001099328
609
67247
Y402
S
Q
H
D
I
S
F
Y
E
A
L
E
S
D
P
Dog
Lupus familis
XP_541830
616
67598
H409
S
Q
H
D
I
S
F
H
E
A
L
E
S
D
P
Cat
Felis silvestris
Mouse
Mus musculus
Q3TIU4
608
67495
Q401
S
Q
H
D
I
S
F
Q
E
A
L
K
S
D
P
Rat
Rattus norvegicus
Q6AXQ5
608
67158
Q401
S
Q
H
D
I
S
F
Q
E
A
L
K
S
D
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511095
639
68679
N432
S
R
H
D
I
A
L
N
Q
A
L
L
S
D
P
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001038753
591
65883
S380
E
Q
Y
D
V
M
L
S
E
A
L
T
T
D
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_723735
564
64146
N367
L
W
N
K
I
K
V
N
A
Q
L
A
E
R
I
Honey Bee
Apis mellifera
XP_001121328
441
50969
S244
N
E
F
N
T
V
W
S
Q
I
Q
D
V
S
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784408
1354
152949
A1138
E
Q
Y
D
I
S
L
A
E
A
F
Q
K
E
S
Poplar Tree
Populus trichocarpa
XP_002323345
603
66902
D391
A
L
N
R
L
V
K
D
N
V
A
L
I
V
V
Maize
Zea mays
NP_001146094
605
67010
D393
A
L
S
R
L
I
K
D
N
I
A
L
I
A
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F8
603
67035
K388
T
A
L
N
R
L
V
K
D
N
I
A
L
I
V
Baker's Yeast
Sacchar. cerevisiae
P31384
837
94681
S619
T
K
D
A
M
D
F
S
G
A
W
M
K
H
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.8
92.3
N.A.
88.3
89.8
N.A.
74.3
N.A.
N.A.
54.6
N.A.
33.9
29.3
N.A.
20.3
Protein Similarity:
100
99.1
99.1
95.9
N.A.
92.2
93
N.A.
82.3
N.A.
N.A.
71
N.A.
51
45.3
N.A.
30.6
P-Site Identity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
60
N.A.
N.A.
46.6
N.A.
13.3
0
N.A.
40
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
80
N.A.
N.A.
66.6
N.A.
20
40
N.A.
60
Percent
Protein Identity:
25.4
25.2
N.A.
25.9
21.1
N.A.
Protein Similarity:
41.8
43.1
N.A.
42.6
34.7
N.A.
P-Site Identity:
0
0
N.A.
0
13.3
N.A.
P-Site Similarity:
20
13.3
N.A.
26.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
0
7
0
7
0
7
7
67
14
14
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
60
0
7
0
14
7
0
0
7
0
54
0
% D
% Glu:
14
7
0
0
0
0
0
0
54
0
0
27
7
7
0
% E
% Phe:
0
0
7
0
0
0
47
0
0
0
7
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% G
% His:
0
0
47
0
0
0
0
7
0
0
0
0
0
7
0
% H
% Ile:
0
0
0
0
60
7
0
0
0
14
7
0
14
7
7
% I
% Lys:
0
7
0
7
0
7
14
7
0
0
0
14
14
0
7
% K
% Leu:
7
14
7
0
14
7
20
0
0
0
60
20
7
0
0
% L
% Met:
0
0
0
0
7
7
0
0
0
0
0
7
0
0
0
% M
% Asn:
7
0
14
14
0
0
0
14
14
7
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
54
% P
% Gln:
0
54
0
0
0
0
0
14
14
7
7
7
0
0
0
% Q
% Arg:
0
7
0
14
7
0
0
0
0
0
0
0
0
7
0
% R
% Ser:
47
0
7
0
0
47
0
20
0
0
0
0
47
7
7
% S
% Thr:
14
0
0
0
7
0
0
0
0
0
0
7
7
0
7
% T
% Val:
0
0
0
0
7
14
14
0
0
7
0
0
7
7
20
% V
% Trp:
0
7
0
0
0
0
7
0
0
0
7
0
0
0
0
% W
% Tyr:
0
0
14
0
0
0
0
20
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _