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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE12 All Species: 30.3
Human Site: Y549 Identified Species: 47.62
UniProt: Q6L8Q7 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6L8Q7 NP_808881.3 609 67352 Y549 S A C G E P A Y T N Y V G G F
Chimpanzee Pan troglodytes XP_517033 609 67371 Y549 S A C G E P A Y T N Y V G G F
Rhesus Macaque Macaca mulatta XP_001099328 609 67247 Y549 S A C G E P A Y T N Y V G G F
Dog Lupus familis XP_541830 616 67598 Y556 S A C G E P A Y T N Y V G G F
Cat Felis silvestris
Mouse Mus musculus Q3TIU4 608 67495 Y548 S A C G E P A Y T N Y V G G F
Rat Rattus norvegicus Q6AXQ5 608 67158 Y548 S A C G E P A Y T N Y V G G F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511095 639 68679 Y579 S A C G E P A Y T N Y V G G F
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038753 591 65883 F527 S A C G V P D F T N F V G G F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_723735 564 64146 C512 Y T T L F A G C L D Y V F Y Q
Honey Bee Apis mellifera XP_001121328 441 50969 G389 N Y T A T F S G C L D Y I F Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784408 1354 152949 Y1292 N A C T S Q E Y T N F V A G F
Poplar Tree Populus trichocarpa XP_002323345 603 66902 F538 A T T N E P L F T N C T R D F
Maize Zea mays NP_001146094 605 67010 F540 P A T N E P L F T N C T R D F
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M2F8 603 67035 F537 L N T N E P L F T N C T R D F
Baker's Yeast Sacchar. cerevisiae P31384 837 94681 F768 N C I G E L P F T N F T P S F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 98.8 92.3 N.A. 88.3 89.8 N.A. 74.3 N.A. N.A. 54.6 N.A. 33.9 29.3 N.A. 20.3
Protein Similarity: 100 99.1 99.1 95.9 N.A. 92.2 93 N.A. 82.3 N.A. N.A. 71 N.A. 51 45.3 N.A. 30.6
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 N.A. N.A. 73.3 N.A. 13.3 0 N.A. 53.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 N.A. N.A. 86.6 N.A. 20 20 N.A. 66.6
Percent
Protein Identity: 25.4 25.2 N.A. 25.9 21.1 N.A.
Protein Similarity: 41.8 43.1 N.A. 42.6 34.7 N.A.
P-Site Identity: 33.3 40 N.A. 33.3 33.3 N.A.
P-Site Similarity: 46.6 46.6 N.A. 40 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 67 0 7 0 7 47 0 0 0 0 0 7 0 0 % A
% Cys: 0 7 60 0 0 0 0 7 7 0 20 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 7 0 0 7 7 0 0 20 0 % D
% Glu: 0 0 0 0 74 0 7 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 7 7 0 34 0 0 20 0 7 7 87 % F
% Gly: 0 0 0 60 0 0 7 7 0 0 0 0 54 60 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 7 0 0 0 0 0 0 0 0 0 7 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 7 0 0 7 0 7 20 0 7 7 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 20 7 0 20 0 0 0 0 0 87 0 0 0 0 0 % N
% Pro: 7 0 0 0 0 74 7 0 0 0 0 0 7 0 0 % P
% Gln: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 % R
% Ser: 54 0 0 0 7 0 7 0 0 0 0 0 0 7 0 % S
% Thr: 0 14 34 7 7 0 0 0 87 0 0 27 0 0 0 % T
% Val: 0 0 0 0 7 0 0 0 0 0 0 67 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 7 0 0 0 0 0 54 0 0 54 7 0 7 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _