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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE12
All Species:
28.48
Human Site:
Y552
Identified Species:
44.76
UniProt:
Q6L8Q7
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6L8Q7
NP_808881.3
609
67352
Y552
G
E
P
A
Y
T
N
Y
V
G
G
F
H
G
C
Chimpanzee
Pan troglodytes
XP_517033
609
67371
Y552
G
E
P
A
Y
T
N
Y
V
G
G
F
H
G
C
Rhesus Macaque
Macaca mulatta
XP_001099328
609
67247
Y552
G
E
P
A
Y
T
N
Y
V
G
G
F
H
G
C
Dog
Lupus familis
XP_541830
616
67598
Y559
G
E
P
A
Y
T
N
Y
V
G
G
F
H
G
C
Cat
Felis silvestris
Mouse
Mus musculus
Q3TIU4
608
67495
Y551
G
E
P
A
Y
T
N
Y
V
G
G
F
H
G
C
Rat
Rattus norvegicus
Q6AXQ5
608
67158
Y551
G
E
P
A
Y
T
N
Y
V
G
G
F
H
G
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511095
639
68679
Y582
G
E
P
A
Y
T
N
Y
V
G
G
F
H
G
C
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001038753
591
65883
F530
G
V
P
D
F
T
N
F
V
G
G
F
Q
G
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_723735
564
64146
Y515
L
F
A
G
C
L
D
Y
V
F
Y
Q
N
D
R
Honey Bee
Apis mellifera
XP_001121328
441
50969
D392
A
T
F
S
G
C
L
D
Y
I
F
Y
Q
T
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784408
1354
152949
F1295
T
S
Q
E
Y
T
N
F
V
A
G
F
V
A
S
Poplar Tree
Populus trichocarpa
XP_002323345
603
66902
C541
N
E
P
L
F
T
N
C
T
R
D
F
I
G
T
Maize
Zea mays
NP_001146094
605
67010
C543
N
E
P
L
F
T
N
C
T
R
D
F
T
G
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F8
603
67035
C540
N
E
P
L
F
T
N
C
T
R
D
F
I
G
T
Baker's Yeast
Sacchar. cerevisiae
P31384
837
94681
F771
G
E
L
P
F
T
N
F
T
P
S
F
T
D
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.8
92.3
N.A.
88.3
89.8
N.A.
74.3
N.A.
N.A.
54.6
N.A.
33.9
29.3
N.A.
20.3
Protein Similarity:
100
99.1
99.1
95.9
N.A.
92.2
93
N.A.
82.3
N.A.
N.A.
71
N.A.
51
45.3
N.A.
30.6
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
N.A.
N.A.
66.6
N.A.
13.3
0
N.A.
40
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
N.A.
N.A.
80
N.A.
26.6
13.3
N.A.
46.6
Percent
Protein Identity:
25.4
25.2
N.A.
25.9
21.1
N.A.
Protein Similarity:
41.8
43.1
N.A.
42.6
34.7
N.A.
P-Site Identity:
40
40
N.A.
40
33.3
N.A.
P-Site Similarity:
46.6
46.6
N.A.
46.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
47
0
0
0
0
0
7
0
0
0
7
0
% A
% Cys:
0
0
0
0
7
7
0
20
0
0
0
0
0
0
54
% C
% Asp:
0
0
0
7
0
0
7
7
0
0
20
0
0
14
7
% D
% Glu:
0
74
0
7
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
7
7
0
34
0
0
20
0
7
7
87
0
0
0
% F
% Gly:
60
0
0
7
7
0
0
0
0
54
60
0
0
74
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
47
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
7
0
0
14
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
7
0
7
20
0
7
7
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
20
0
0
0
0
0
87
0
0
0
0
0
7
0
0
% N
% Pro:
0
0
74
7
0
0
0
0
0
7
0
0
0
0
0
% P
% Gln:
0
0
7
0
0
0
0
0
0
0
0
7
14
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
20
0
0
0
0
7
% R
% Ser:
0
7
0
7
0
0
0
0
0
0
7
0
0
0
7
% S
% Thr:
7
7
0
0
0
87
0
0
27
0
0
0
14
7
20
% T
% Val:
0
7
0
0
0
0
0
0
67
0
0
0
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
54
0
0
54
7
0
7
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _