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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TET2
All Species:
9.09
Human Site:
T549
Identified Species:
25
UniProt:
Q6N021
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6N021
NP_001120680.1
2002
223811
T549
K
G
R
D
K
E
Q
T
R
D
L
V
P
P
T
Chimpanzee
Pan troglodytes
XP_526645
2142
238185
T689
K
G
R
D
K
E
Q
T
R
D
L
V
P
P
T
Rhesus Macaque
Macaca mulatta
XP_001082522
1163
129991
Dog
Lupus familis
XP_535678
2098
234866
T664
K
G
R
D
K
E
Q
T
R
G
L
V
L
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q4JK59
1912
212111
W524
S
V
Q
A
A
P
G
W
I
E
L
K
A
P
N
Rat
Rattus norvegicus
XP_001077411
1920
212372
V525
K
G
Q
T
Q
G
S
V
L
A
A
P
G
W
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_421571
2245
248077
K587
L
P
M
L
E
K
K
K
R
R
R
C
G
V
C
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_685016
1354
150288
G12
Y
R
R
S
V
E
E
G
T
T
T
P
L
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_396330
2736
305043
S686
P
L
Q
P
G
P
Q
S
L
H
N
S
N
G
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.7
55.3
81.6
N.A.
59.9
61.2
N.A.
N.A.
31.4
N.A.
35.7
N.A.
N.A.
24.3
N.A.
N.A.
Protein Similarity:
100
92.9
56.4
85.2
N.A.
70.9
71.6
N.A.
N.A.
47.8
N.A.
49
N.A.
N.A.
39.1
N.A.
N.A.
P-Site Identity:
100
100
0
80
N.A.
13.3
13.3
N.A.
N.A.
6.6
N.A.
13.3
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
100
100
0
80
N.A.
26.6
26.6
N.A.
N.A.
26.6
N.A.
20
N.A.
N.A.
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
12
12
0
0
0
0
12
12
0
12
0
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
12
% C
% Asp:
0
0
0
34
0
0
0
0
0
23
0
0
0
0
0
% D
% Glu:
0
0
0
0
12
45
12
0
0
12
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
45
0
0
12
12
12
12
0
12
0
0
23
12
0
% G
% His:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
12
% I
% Lys:
45
0
0
0
34
12
12
12
0
0
0
12
0
0
0
% K
% Leu:
12
12
0
12
0
0
0
0
23
0
45
0
23
12
0
% L
% Met:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
12
0
12
0
12
% N
% Pro:
12
12
0
12
0
23
0
0
0
0
0
23
23
45
12
% P
% Gln:
0
0
34
0
12
0
45
0
0
0
0
0
0
0
0
% Q
% Arg:
0
12
45
0
0
0
0
0
45
12
12
0
0
0
0
% R
% Ser:
12
0
0
12
0
0
12
12
0
0
0
12
0
0
0
% S
% Thr:
0
0
0
12
0
0
0
34
12
12
12
0
0
0
23
% T
% Val:
0
12
0
0
12
0
0
12
0
0
0
34
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
12
0
0
0
0
0
12
0
% W
% Tyr:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _