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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LRRC8E
All Species:
31.21
Human Site:
Y252
Identified Species:
68.67
UniProt:
Q6NSJ5
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6NSJ5
NP_079337
796
90247
Y252
V
E
E
G
D
I
L
Y
T
M
Y
I
R
Q
T
Chimpanzee
Pan troglodytes
XP_001160980
841
97525
Y292
V
E
E
G
D
I
V
Y
R
L
Y
M
R
Q
T
Rhesus Macaque
Macaca mulatta
XP_001093244
796
90155
Y252
V
E
E
G
D
I
L
Y
T
M
Y
I
R
Q
T
Dog
Lupus familis
XP_542121
793
90047
Y249
V
E
E
G
D
I
L
Y
T
M
Y
I
R
Q
T
Cat
Felis silvestris
Mouse
Mus musculus
Q66JT1
795
90416
Y251
V
E
E
G
D
I
L
Y
S
M
Y
I
R
Q
T
Rat
Rattus norvegicus
Q3KRC6
795
90427
Y251
V
E
E
G
D
I
L
Y
S
M
Y
I
R
Q
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520382
756
86845
Y212
V
E
E
G
D
I
L
Y
A
M
Y
V
R
Q
T
Chicken
Gallus gallus
Q5F4C4
529
59144
R82
P
N
P
A
T
G
T
R
K
K
S
S
N
A
E
Frog
Xenopus laevis
Q6NU09
806
92226
Y262
V
E
E
G
D
L
L
Y
S
M
Y
M
R
Q
T
Zebra Danio
Brachydanio rerio
Q1L8Y7
561
62677
L114
L
Y
L
Y
S
N
K
L
Q
S
L
P
P
E
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22875
559
62465
P112
K
N
K
L
T
C
L
P
T
E
I
G
Q
L
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
50.5
98.1
92.4
N.A.
89.8
90.9
N.A.
56.1
22.8
65.6
20.3
N.A.
N.A.
N.A.
20.8
N.A.
Protein Similarity:
100
67.7
98.8
95.7
N.A.
94.8
95.2
N.A.
72.8
35.6
79.2
35.6
N.A.
N.A.
N.A.
37.5
N.A.
P-Site Identity:
100
73.3
100
100
N.A.
93.3
93.3
N.A.
86.6
0
80
0
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
93.3
100
100
N.A.
100
100
N.A.
93.3
0
100
13.3
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
0
0
0
10
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
73
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
73
73
0
0
0
0
0
0
10
0
0
0
10
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
73
0
10
0
0
0
0
0
10
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
64
0
0
0
0
10
46
0
0
0
% I
% Lys:
10
0
10
0
0
0
10
0
10
10
0
0
0
0
0
% K
% Leu:
10
0
10
10
0
10
73
10
0
10
10
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
64
0
19
0
0
0
% M
% Asn:
0
19
0
0
0
10
0
0
0
0
0
0
10
0
0
% N
% Pro:
10
0
10
0
0
0
0
10
0
0
0
10
10
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
10
0
0
0
10
73
0
% Q
% Arg:
0
0
0
0
0
0
0
10
10
0
0
0
73
0
0
% R
% Ser:
0
0
0
0
10
0
0
0
28
10
10
10
0
0
0
% S
% Thr:
0
0
0
0
19
0
10
0
37
0
0
0
0
0
73
% T
% Val:
73
0
0
0
0
0
10
0
0
0
0
10
0
0
19
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
10
0
0
0
73
0
0
73
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _