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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LRRC8E All Species: 28.48
Human Site: Y296 Identified Species: 62.67
UniProt: Q6NSJ5 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6NSJ5 NP_079337 796 90247 Y296 E T S E V T G Y A S F C C N H
Chimpanzee Pan troglodytes XP_001160980 841 97525 Y336 D I E S L T G Y R T Y R C A H
Rhesus Macaque Macaca mulatta XP_001093244 796 90155 Y296 E T S E V T G Y A S F C C N H
Dog Lupus familis XP_542121 793 90047 Y293 E T S E V T G Y A S F C C N H
Cat Felis silvestris
Mouse Mus musculus Q66JT1 795 90416 Y295 E T S E I T G Y A S F C C N H
Rat Rattus norvegicus Q3KRC6 795 90427 Y295 E T S E I T G Y A S F C C N H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520382 756 86845 Y256 D I Q D M T G Y K H F S C N H
Chicken Gallus gallus Q5F4C4 529 59144 T126 V K E L T Q L T E L Y L Y S N
Frog Xenopus laevis Q6NU09 806 92226 Y306 H T E D M T G Y N S F C C N H
Zebra Danio Brachydanio rerio Q1L8Y7 561 62677 N158 R M L D L R H N K L R E I P A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22875 559 62465 E156 L R H N K L T E V P S V I Y K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 50.5 98.1 92.4 N.A. 89.8 90.9 N.A. 56.1 22.8 65.6 20.3 N.A. N.A. N.A. 20.8 N.A.
Protein Similarity: 100 67.7 98.8 95.7 N.A. 94.8 95.2 N.A. 72.8 35.6 79.2 35.6 N.A. N.A. N.A. 37.5 N.A.
P-Site Identity: 100 33.3 100 100 N.A. 93.3 93.3 N.A. 46.6 0 66.6 0 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 60 100 100 N.A. 100 100 N.A. 66.6 20 80 13.3 N.A. N.A. N.A. 0 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 46 0 0 0 0 10 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 55 73 0 0 % C
% Asp: 19 0 0 28 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 46 0 28 46 0 0 0 10 10 0 0 10 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 64 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 73 0 0 0 0 0 0 0 0 % G
% His: 10 0 10 0 0 0 10 0 0 10 0 0 0 0 73 % H
% Ile: 0 19 0 0 19 0 0 0 0 0 0 0 19 0 0 % I
% Lys: 0 10 0 0 10 0 0 0 19 0 0 0 0 0 10 % K
% Leu: 10 0 10 10 19 10 10 0 0 19 0 10 0 0 0 % L
% Met: 0 10 0 0 19 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 10 0 0 0 10 10 0 0 0 0 64 10 % N
% Pro: 0 0 0 0 0 0 0 0 0 10 0 0 0 10 0 % P
% Gln: 0 0 10 0 0 10 0 0 0 0 0 0 0 0 0 % Q
% Arg: 10 10 0 0 0 10 0 0 10 0 10 10 0 0 0 % R
% Ser: 0 0 46 10 0 0 0 0 0 55 10 10 0 10 0 % S
% Thr: 0 55 0 0 10 73 10 10 0 10 0 0 0 0 0 % T
% Val: 10 0 0 0 28 0 0 0 10 0 0 10 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 73 0 0 19 0 10 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _