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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TYW1B All Species: 18.79
Human Site: S163 Identified Species: 37.58
UniProt: Q6NUM6 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6NUM6 NP_001138912.1 668 76946 S163 L G V H R V M S R G E G D C D
Chimpanzee Pan troglodytes XP_001149962 340 38388
Rhesus Macaque Macaca mulatta XP_001091335 749 86027 S226 L G A H R V M S R G E G D C D
Dog Lupus familis XP_536836 714 81505 A214 L G A H R V V A R G E G D C D
Cat Felis silvestris
Mouse Mus musculus Q8BJM7 721 81581 T201 L G A Q R V L T R G E G D C N
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_415726 741 84009 T218 L S A R R I M T R A E G D C N
Frog Xenopus laevis Q2KHP8 735 84095 T213 L S A N R V M T R A E G D C N
Zebra Danio Brachydanio rerio Q08C92 730 83531 T209 L S A A R I M T R G E G D C N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188746 713 80418 P212 L S A R P L L P V G E G N G N
Poplar Tree Populus trichocarpa XP_002301868 592 66250 E154 L A R V L K G E S V E N G E V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RXN5 647 72062 G167 E L S S R M I G L G G L E M I
Baker's Yeast Sacchar. cerevisiae Q08960 810 89787 R290 E E N A N D F R V D S F P L R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 22.7 81.1 77.3 N.A. 72.2 N.A. N.A. N.A. 63.2 63.9 62.3 N.A. N.A. N.A. N.A. 48.1
Protein Similarity: 100 32.1 83.8 83.4 N.A. 81.1 N.A. N.A. N.A. 74 75.2 74.7 N.A. N.A. N.A. N.A. 63.8
P-Site Identity: 100 0 93.3 80 N.A. 66.6 N.A. N.A. N.A. 53.3 60 60 N.A. N.A. N.A. N.A. 26.6
P-Site Similarity: 100 0 93.3 93.3 N.A. 86.6 N.A. N.A. N.A. 73.3 80 80 N.A. N.A. N.A. N.A. 53.3
Percent
Protein Identity: 42 N.A. N.A. 41.4 29.8 N.A.
Protein Similarity: 57.1 N.A. N.A. 57.7 46.3 N.A.
P-Site Identity: 13.3 N.A. N.A. 13.3 0 N.A.
P-Site Similarity: 13.3 N.A. N.A. 33.3 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 59 17 0 0 0 9 0 17 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 59 0 % C
% Asp: 0 0 0 0 0 9 0 0 0 9 0 0 59 0 25 % D
% Glu: 17 9 0 0 0 0 0 9 0 0 75 0 9 9 0 % E
% Phe: 0 0 0 0 0 0 9 0 0 0 0 9 0 0 0 % F
% Gly: 0 34 0 0 0 0 9 9 0 59 9 67 9 9 0 % G
% His: 0 0 0 25 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 17 9 0 0 0 0 0 0 0 9 % I
% Lys: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % K
% Leu: 75 9 0 0 9 9 17 0 9 0 0 9 0 9 0 % L
% Met: 0 0 0 0 0 9 42 0 0 0 0 0 0 9 0 % M
% Asn: 0 0 9 9 9 0 0 0 0 0 0 9 9 0 42 % N
% Pro: 0 0 0 0 9 0 0 9 0 0 0 0 9 0 0 % P
% Gln: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 9 17 67 0 0 9 59 0 0 0 0 0 9 % R
% Ser: 0 34 9 9 0 0 0 17 9 0 9 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 34 0 0 0 0 0 0 0 % T
% Val: 0 0 9 9 0 42 9 0 17 9 0 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _