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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TYW1B
All Species:
7.58
Human Site:
S248
Identified Species:
15.15
UniProt:
Q6NUM6
Number Species:
11
Phosphosite Substitution
Charge Score:
0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6NUM6
NP_001138912.1
668
76946
S248
K
E
E
E
P
F
E
S
S
S
E
E
E
F
G
Chimpanzee
Pan troglodytes
XP_001149962
340
38388
Rhesus Macaque
Macaca mulatta
XP_001091335
749
86027
S311
E
E
E
E
P
F
E
S
S
S
E
E
E
F
G
Dog
Lupus familis
XP_536836
714
81505
L299
S
V
V
D
V
E
D
L
G
K
I
M
N
C
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJM7
721
81581
E286
E
P
C
E
S
S
S
E
D
E
L
G
T
Q
D
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415726
741
84009
E303
E
L
F
E
T
T
S
E
E
E
A
D
A
E
E
Frog
Xenopus laevis
Q2KHP8
735
84095
T298
T
E
D
D
T
F
E
T
S
S
D
S
E
P
E
Zebra Danio
Brachydanio rerio
Q08C92
730
83531
E294
M
E
S
S
S
D
E
E
S
S
S
E
D
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001188746
713
80418
Q297
D
D
G
L
D
S
D
Q
E
D
P
D
E
M
D
Poplar Tree
Populus trichocarpa
XP_002301868
592
66250
I239
L
E
K
Q
G
Y
K
I
I
G
S
H
S
G
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RXN5
647
72062
A252
L
E
D
I
A
G
K
A
P
S
K
R
N
G
V
Baker's Yeast
Sacchar. cerevisiae
Q08960
810
89787
E375
P
I
I
Y
E
Y
D
E
N
A
D
S
E
E
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
22.7
81.1
77.3
N.A.
72.2
N.A.
N.A.
N.A.
63.2
63.9
62.3
N.A.
N.A.
N.A.
N.A.
48.1
Protein Similarity:
100
32.1
83.8
83.4
N.A.
81.1
N.A.
N.A.
N.A.
74
75.2
74.7
N.A.
N.A.
N.A.
N.A.
63.8
P-Site Identity:
100
0
93.3
0
N.A.
6.6
N.A.
N.A.
N.A.
6.6
40
33.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
0
100
13.3
N.A.
13.3
N.A.
N.A.
N.A.
20
66.6
40
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
42
N.A.
N.A.
41.4
29.8
N.A.
Protein Similarity:
57.1
N.A.
N.A.
57.7
46.3
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
40
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
0
9
0
9
9
0
9
0
0
% A
% Cys:
0
0
9
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
9
9
17
17
9
9
25
0
9
9
17
17
9
0
25
% D
% Glu:
25
50
17
34
9
9
34
34
17
17
17
25
42
25
17
% E
% Phe:
0
0
9
0
0
25
0
0
0
0
0
0
0
17
0
% F
% Gly:
0
0
9
0
9
9
0
0
9
9
0
9
0
17
17
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% H
% Ile:
0
9
9
9
0
0
0
9
9
0
9
0
0
0
0
% I
% Lys:
9
0
9
0
0
0
17
0
0
9
9
0
0
0
9
% K
% Leu:
17
9
0
9
0
0
0
9
0
0
9
0
0
0
0
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
9
0
9
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
0
0
0
17
0
0
% N
% Pro:
9
9
0
0
17
0
0
0
9
0
9
0
0
9
0
% P
% Gln:
0
0
0
9
0
0
0
9
0
0
0
0
0
9
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% R
% Ser:
9
0
9
9
17
17
17
17
34
42
17
17
9
0
0
% S
% Thr:
9
0
0
0
17
9
0
9
0
0
0
0
9
0
0
% T
% Val:
0
9
9
0
9
0
0
0
0
0
0
0
0
0
25
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
17
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _