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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HIBCH
All Species:
37.27
Human Site:
S289
Identified Species:
58.57
UniProt:
Q6NVY1
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6NVY1
NP_055177.2
386
43482
S289
E
N
L
Q
Q
D
G
S
S
F
A
L
E
Q
L
Chimpanzee
Pan troglodytes
XP_515988
440
48807
S343
E
N
L
Q
Q
D
G
S
S
F
A
L
E
Q
L
Rhesus Macaque
Macaca mulatta
XP_001103467
444
49874
S347
E
N
L
K
Q
D
G
S
S
F
A
L
E
Q
L
Dog
Lupus familis
XP_848689
359
39946
V271
F
A
L
E
Q
L
K
V
I
N
K
M
S
P
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8QZS1
385
43019
S288
E
N
L
R
Q
D
G
S
P
F
A
I
E
Q
M
Rat
Rattus norvegicus
Q5XIE6
385
43006
S288
E
N
L
R
Q
D
G
S
P
F
A
M
E
Q
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJ60
385
42810
S288
Q
K
L
K
Q
D
G
S
P
F
A
T
K
Q
L
Frog
Xenopus laevis
A2VDC2
385
42348
S288
E
N
L
K
C
D
G
S
S
F
A
M
K
Q
L
Zebra Danio
Brachydanio rerio
Q58EB4
382
42258
S285
E
N
L
K
K
D
G
S
A
F
A
L
K
Q
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650453
385
42729
T293
G
S
E
W
A
K
K
T
L
E
T
L
S
K
M
Honey Bee
Apis mellifera
XP_396249
396
44074
T294
N
S
E
W
A
K
K
T
L
Q
M
L
L
K
A
Nematode Worm
Caenorhab. elegans
P34559
288
31153
E200
G
N
H
V
T
A
Q
E
A
K
E
H
G
I
V
Sea Urchin
Strong. purpuratus
XP_791196
379
41899
S282
Q
N
L
E
Q
D
G
S
E
W
A
T
K
Q
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q1PEY5
378
42237
E286
I
S
L
R
S
I
R
E
G
R
L
Q
G
V
G
Baker's Yeast
Sacchar. cerevisiae
P28817
500
56270
S292
I
E
A
C
F
N
L
S
K
N
G
T
I
E
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.8
84.9
84.4
N.A.
81.8
81.6
N.A.
N.A.
69.1
69.6
65.2
N.A.
49.2
47.9
24.6
56.9
Protein Similarity:
100
86.8
86.2
87.8
N.A.
92.2
92.2
N.A.
N.A.
83.9
81.3
78.2
N.A.
67.6
67.1
40.9
75.1
P-Site Identity:
100
100
93.3
13.3
N.A.
73.3
73.3
N.A.
N.A.
60
73.3
66.6
N.A.
6.6
6.6
6.6
60
P-Site Similarity:
100
100
100
26.6
N.A.
93.3
93.3
N.A.
N.A.
80
93.3
93.3
N.A.
33.3
26.6
20
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
39.1
30.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.8
47
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
0
14
7
0
0
14
0
60
0
0
0
14
% A
% Cys:
0
0
0
7
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
60
0
0
0
0
0
0
0
0
7
% D
% Glu:
47
7
14
14
0
0
0
14
7
7
7
0
34
7
0
% E
% Phe:
7
0
0
0
7
0
0
0
0
54
0
0
0
0
0
% F
% Gly:
14
0
0
0
0
0
60
0
7
0
7
0
14
0
7
% G
% His:
0
0
7
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
14
0
0
0
0
7
0
0
7
0
0
7
7
7
7
% I
% Lys:
0
7
0
27
7
14
20
0
7
7
7
0
27
14
0
% K
% Leu:
0
0
74
0
0
7
7
0
14
0
7
40
7
0
40
% L
% Met:
0
0
0
0
0
0
0
0
0
0
7
20
0
0
14
% M
% Asn:
7
60
0
0
0
7
0
0
0
14
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
20
0
0
0
0
7
0
% P
% Gln:
14
0
0
14
54
0
7
0
0
7
0
7
0
60
0
% Q
% Arg:
0
0
0
20
0
0
7
0
0
7
0
0
0
0
0
% R
% Ser:
0
20
0
0
7
0
0
67
27
0
0
0
14
0
0
% S
% Thr:
0
0
0
0
7
0
0
14
0
0
7
20
0
0
7
% T
% Val:
0
0
0
7
0
0
0
7
0
0
0
0
0
7
7
% V
% Trp:
0
0
0
14
0
0
0
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _