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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIBCH All Species: 13.03
Human Site: S29 Identified Species: 20.48
UniProt: Q6NVY1 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6NVY1 NP_055177.2 386 43482 S29 I L H H L R M S K H T D A A E
Chimpanzee Pan troglodytes XP_515988 440 48807 S83 I L H H L R M S K H T D A A E
Rhesus Macaque Macaca mulatta XP_001103467 444 49874 S87 I L H H L R M S K H T D A A E
Dog Lupus familis XP_848689 359 39946 I22 R R G C A G V I T L N R P K F
Cat Felis silvestris
Mouse Mus musculus Q8QZS1 385 43019 M28 V I L Q H L R M S M H T E A A
Rat Rattus norvegicus Q5XIE6 385 43006 M28 V I L Q H L R M S K H T E T A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZJ60 385 42810 C28 I L Q H L K T C K H T D S A A
Frog Xenopus laevis A2VDC2 385 42348 S28 I R Q H L R M S N H T V K D G
Zebra Danio Brachydanio rerio Q58EB4 382 42258 S27 R I H G H M M S S K A G S E V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650453 385 42729 L37 T K P T T M A L S V R Q S S S
Honey Bee Apis mellifera XP_396249 396 44074 A34 T S G G G K E A Q Q T N I E N
Nematode Worm Caenorhab. elegans P34559 288 31153
Sea Urchin Strong. purpuratus XP_791196 379 41899 G26 M R M S S T A G T E E D A L F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q1PEY5 378 42237 H32 Q L N A L S F H M V S R L L Q
Baker's Yeast Sacchar. cerevisiae P28817 500 56270 Q30 T F M T T Q P Q L N V T D A P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86.8 84.9 84.4 N.A. 81.8 81.6 N.A. N.A. 69.1 69.6 65.2 N.A. 49.2 47.9 24.6 56.9
Protein Similarity: 100 86.8 86.2 87.8 N.A. 92.2 92.2 N.A. N.A. 83.9 81.3 78.2 N.A. 67.6 67.1 40.9 75.1
P-Site Identity: 100 100 100 0 N.A. 6.6 0 N.A. N.A. 60 53.3 20 N.A. 0 6.6 0 13.3
P-Site Similarity: 100 100 100 6.6 N.A. 20 13.3 N.A. N.A. 73.3 53.3 33.3 N.A. 13.3 33.3 0 20
Percent
Protein Identity: N.A. N.A. N.A. 39.1 30.2 N.A.
Protein Similarity: N.A. N.A. N.A. 59.8 47 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 7 0 14 7 0 0 7 0 27 40 20 % A
% Cys: 0 0 0 7 0 0 0 7 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 34 7 7 0 % D
% Glu: 0 0 0 0 0 0 7 0 0 7 7 0 14 14 20 % E
% Phe: 0 7 0 0 0 0 7 0 0 0 0 0 0 0 14 % F
% Gly: 0 0 14 14 7 7 0 7 0 0 0 7 0 0 7 % G
% His: 0 0 27 34 20 0 0 7 0 34 14 0 0 0 0 % H
% Ile: 34 20 0 0 0 0 0 7 0 0 0 0 7 0 0 % I
% Lys: 0 7 0 0 0 14 0 0 27 14 0 0 7 7 0 % K
% Leu: 0 34 14 0 40 14 0 7 7 7 0 0 7 14 0 % L
% Met: 7 0 14 0 0 14 34 14 7 7 0 0 0 0 0 % M
% Asn: 0 0 7 0 0 0 0 0 7 7 7 7 0 0 7 % N
% Pro: 0 0 7 0 0 0 7 0 0 0 0 0 7 0 7 % P
% Gln: 7 0 14 14 0 7 0 7 7 7 0 7 0 0 7 % Q
% Arg: 14 20 0 0 0 27 14 0 0 0 7 14 0 0 0 % R
% Ser: 0 7 0 7 7 7 0 34 27 0 7 0 20 7 7 % S
% Thr: 20 0 0 14 14 7 7 0 14 0 40 20 0 7 0 % T
% Val: 14 0 0 0 0 0 7 0 0 14 7 7 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _