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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF40B
All Species:
25.76
Human Site:
S425
Identified Species:
51.52
UniProt:
Q6NWY9
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6NWY9
NP_001026868.1
871
99358
S425
K
S
I
L
D
G
M
S
S
V
N
F
Q
T
T
Chimpanzee
Pan troglodytes
XP_001144883
893
101489
S447
K
S
I
L
D
G
M
S
S
V
N
F
Q
T
T
Rhesus Macaque
Macaca mulatta
XP_001101626
863
97737
S460
K
S
I
L
D
G
M
S
S
V
N
F
Q
T
T
Dog
Lupus familis
XP_534809
997
112581
S551
K
S
I
L
D
G
M
S
S
V
N
F
Q
T
T
Cat
Felis silvestris
Mouse
Mus musculus
Q80W14
870
99281
S425
K
S
I
L
D
G
M
S
S
V
N
F
Q
T
T
Rat
Rattus norvegicus
NP_001128055
867
99008
S423
K
S
I
L
D
G
M
S
S
V
N
F
Q
T
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508338
855
97709
A484
K
N
I
L
D
N
M
A
N
V
T
Y
S
T
T
Chicken
Gallus gallus
NP_989492
853
96992
A482
K
N
I
L
D
N
M
A
N
V
T
Y
C
T
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_938170
851
97677
A436
K
N
I
L
D
N
M
A
N
V
T
Y
R
T
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608738
806
91309
T378
G
E
L
L
E
S
M
T
S
I
N
H
A
T
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34600
724
84646
D354
I
D
F
V
A
R
R
D
K
E
K
K
E
E
D
Sea Urchin
Strong. purpuratus
XP_001178122
1501
164734
P821
N
N
I
L
D
S
M
P
N
V
T
F
R
T
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.3
93.6
85
N.A.
95.5
95
N.A.
57
57.6
N.A.
60.8
N.A.
40.4
N.A.
31.9
34.6
Protein Similarity:
100
97.5
94
86
N.A.
97.5
97.1
N.A.
71.8
71.6
N.A.
74.7
N.A.
57.6
N.A.
52
44.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
53.3
53.3
N.A.
53.3
N.A.
40
N.A.
0
53.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
80
80
N.A.
86.6
N.A.
66.6
N.A.
13.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
0
25
0
0
0
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% C
% Asp:
0
9
0
0
84
0
0
9
0
0
0
0
0
0
9
% D
% Glu:
0
9
0
0
9
0
0
0
0
9
0
0
9
9
0
% E
% Phe:
0
0
9
0
0
0
0
0
0
0
0
59
0
0
0
% F
% Gly:
9
0
0
0
0
50
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% H
% Ile:
9
0
84
0
0
0
0
0
0
9
0
0
0
0
0
% I
% Lys:
75
0
0
0
0
0
0
0
9
0
9
9
0
0
0
% K
% Leu:
0
0
9
92
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
92
0
0
0
0
0
0
0
0
% M
% Asn:
9
34
0
0
0
25
0
0
34
0
59
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
50
0
0
% Q
% Arg:
0
0
0
0
0
9
9
0
0
0
0
0
17
0
0
% R
% Ser:
0
50
0
0
0
17
0
50
59
0
0
0
9
0
0
% S
% Thr:
0
0
0
0
0
0
0
9
0
0
34
0
0
92
92
% T
% Val:
0
0
0
9
0
0
0
0
0
84
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
25
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _