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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC73
All Species:
22.42
Human Site:
S121
Identified Species:
41.11
UniProt:
Q6P1J9
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P1J9
NP_078805.3
531
60577
S121
L
E
I
G
L
Q
R
S
T
Q
V
K
R
A
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001112520
355
40602
I13
I
A
A
I
K
A
K
I
M
A
K
K
R
S
T
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
NP_666103
531
60558
S121
L
E
I
G
L
Q
R
S
T
Q
V
K
R
A
A
Rat
Rattus norvegicus
Q4V8C8
531
60584
S121
L
E
I
G
L
Q
R
S
T
Q
V
K
R
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516577
745
82627
S335
L
E
I
G
L
Q
R
S
T
Q
V
K
R
A
A
Chicken
Gallus gallus
Q5ZLM0
531
60679
S121
L
E
I
G
L
Q
R
S
T
Q
V
K
R
A
A
Frog
Xenopus laevis
NP_001079512
531
60663
S121
L
E
I
G
L
Q
R
S
T
Q
V
K
R
V
A
Zebra Danio
Brachydanio rerio
NP_956642
521
59412
P121
I
E
I
G
L
Q
R
P
T
Q
V
K
R
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649863
538
61366
K121
L
E
I
P
T
Q
V
K
R
A
A
E
G
E
P
Honey Bee
Apis mellifera
XP_395835
525
59540
K121
L
E
I
P
T
Q
V
K
R
T
A
E
D
G
L
Nematode Worm
Caenorhab. elegans
NP_500465
535
60290
L121
P
L
S
L
R
Q
L
L
H
S
S
E
P
E
A
Sea Urchin
Strong. purpuratus
XP_001192448
532
61126
P121
P
E
I
S
R
Q
R
P
T
Q
V
K
R
S
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q06697
393
44438
L52
S
T
Q
D
S
F
P
L
N
E
E
T
E
I
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
66.8
N.A.
N.A.
100
99.8
N.A.
67.6
97.7
93.9
88.8
N.A.
58.5
65.1
30.8
62.5
Protein Similarity:
100
N.A.
66.8
N.A.
N.A.
100
99.8
N.A.
70
98.6
96.6
92.6
N.A.
73.4
77.5
52.7
75.3
P-Site Identity:
100
N.A.
13.3
N.A.
N.A.
100
100
N.A.
100
100
93.3
86.6
N.A.
26.6
26.6
13.3
66.6
P-Site Similarity:
100
N.A.
33.3
N.A.
N.A.
100
100
N.A.
100
100
93.3
93.3
N.A.
33.3
33.3
20
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
8
0
0
0
16
16
0
0
47
70
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% D
% Glu:
0
77
0
0
0
0
0
0
0
8
8
24
8
16
8
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
54
0
0
0
0
0
0
0
0
8
8
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
16
0
77
8
0
0
0
8
0
0
0
0
0
8
0
% I
% Lys:
0
0
0
0
8
0
8
16
0
0
8
70
0
0
0
% K
% Leu:
62
8
0
8
54
0
8
16
0
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
16
0
0
16
0
0
8
16
0
0
0
0
8
0
8
% P
% Gln:
0
0
8
0
0
85
0
0
0
62
0
0
0
0
0
% Q
% Arg:
0
0
0
0
16
0
62
0
16
0
0
0
70
0
0
% R
% Ser:
8
0
8
8
8
0
0
47
0
8
8
0
0
16
0
% S
% Thr:
0
8
0
0
16
0
0
0
62
8
0
8
0
0
8
% T
% Val:
0
0
0
0
0
0
16
0
0
0
62
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _