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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL2B
All Species:
23.03
Human Site:
T224
Identified Species:
42.22
UniProt:
Q6P1Q9
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P1Q9
NP_060866.2
378
43440
T224
T
A
I
E
L
V
Q
T
N
S
E
Y
D
P
S
Chimpanzee
Pan troglodytes
XP_001152439
378
43448
T224
T
A
I
E
L
V
Q
T
N
S
E
Y
D
P
S
Rhesus Macaque
Macaca mulatta
XP_001116039
379
43675
T225
T
A
I
E
L
V
Q
T
N
P
E
Y
D
P
S
Dog
Lupus familis
XP_537604
474
53846
T320
T
A
V
E
L
V
Q
T
N
S
A
Y
D
P
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8BMK1
389
43893
T217
T
A
I
E
L
L
K
T
N
S
Q
Y
D
P
S
Rat
Rattus norvegicus
Q6AXU8
287
33363
L142
C
D
L
T
R
D
D
L
L
D
H
I
P
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518238
377
41950
A223
T
A
V
D
L
V
Q
A
N
S
E
Y
D
P
S
Chicken
Gallus gallus
Q5ZHP8
370
42711
S217
T
A
V
D
L
V
Q
S
N
V
E
Y
D
S
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A8KBL7
353
40469
S208
S
N
P
E
Y
D
P
S
R
C
H
A
F
V
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q86BS6
325
38113
F180
I
L
R
S
Q
R
Q
F
D
E
K
R
C
E
V
Honey Bee
Apis mellifera
XP_624474
332
39379
S187
L
D
I
L
K
Q
N
S
A
Y
D
T
S
R
C
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001175658
397
45417
Q249
V
A
V
D
I
V
R
Q
H
A
E
Y
N
P
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08641
628
71467
E479
V
E
L
V
K
N
S
E
Q
F
N
P
K
Y
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
97
71.5
N.A.
78.1
34.3
N.A.
67.1
65
N.A.
65.6
N.A.
37.2
51
N.A.
43.5
Protein Similarity:
100
99.2
98.4
75.3
N.A.
84.8
46.5
N.A.
76.4
78.3
N.A.
76.9
N.A.
52.1
63.7
N.A.
59.9
P-Site Identity:
100
100
93.3
80
N.A.
80
6.6
N.A.
80
66.6
N.A.
6.6
N.A.
6.6
6.6
N.A.
40
P-Site Similarity:
100
100
93.3
86.6
N.A.
100
13.3
N.A.
93.3
86.6
N.A.
20
N.A.
20
20
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
37.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
62
0
0
0
0
0
8
8
8
8
8
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
8
0
0
8
0
16
% C
% Asp:
0
16
0
24
0
16
8
0
8
8
8
0
54
0
0
% D
% Glu:
0
8
0
47
0
0
0
8
0
8
47
0
0
8
8
% E
% Phe:
0
0
0
0
0
0
0
8
0
8
0
0
8
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
8
0
16
0
0
0
8
% H
% Ile:
8
0
39
0
8
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
0
0
16
0
8
0
0
0
8
0
8
0
0
% K
% Leu:
8
8
16
8
54
8
0
8
8
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
8
8
0
54
0
8
0
8
0
0
% N
% Pro:
0
0
8
0
0
0
8
0
0
8
0
8
8
62
0
% P
% Gln:
0
0
0
0
8
8
54
8
8
0
8
0
0
0
0
% Q
% Arg:
0
0
8
0
8
8
8
0
8
0
0
8
0
8
0
% R
% Ser:
8
0
0
8
0
0
8
24
0
39
0
0
8
8
54
% S
% Thr:
54
0
0
8
0
0
0
39
0
0
0
8
0
0
0
% T
% Val:
16
0
31
8
0
54
0
0
0
8
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
8
0
62
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _