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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
METTL2B
All Species:
21.82
Human Site:
Y247
Identified Species:
40
UniProt:
Q6P1Q9
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P1Q9
NP_060866.2
378
43440
Y247
L
C
D
E
E
K
S
Y
P
V
P
K
G
S
L
Chimpanzee
Pan troglodytes
XP_001152439
378
43448
Y247
L
C
D
E
E
K
S
Y
P
V
P
K
G
S
L
Rhesus Macaque
Macaca mulatta
XP_001116039
379
43675
Y248
L
C
D
E
E
K
S
Y
P
V
P
K
G
S
L
Dog
Lupus familis
XP_537604
474
53846
Y343
L
C
D
E
D
K
S
Y
P
V
P
R
D
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8BMK1
389
43893
Y240
L
C
D
E
D
Q
S
Y
P
V
P
E
D
S
L
Rat
Rattus norvegicus
Q6AXU8
287
33363
P165
F
V
L
S
A
V
H
P
E
K
M
H
L
V
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518238
377
41950
Y246
L
C
D
E
H
K
S
Y
P
M
P
E
G
S
L
Chicken
Gallus gallus
Q5ZHP8
370
42711
F240
L
C
N
D
Q
S
P
F
P
M
P
D
E
S
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A8KBL7
353
40469
L231
Y
P
M
P
D
H
S
L
D
V
I
V
L
I
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q86BS6
325
38113
E203
H
W
Q
V
P
F
E
E
N
S
Q
D
I
I
V
Honey Bee
Apis mellifera
XP_624474
332
39379
F210
Q
E
E
W
E
T
P
F
E
P
E
S
L
D
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001175658
397
45417
F272
V
S
D
P
A
A
S
F
P
V
P
D
N
S
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q08641
628
71467
D502
N
P
D
G
N
L
P
D
G
V
E
P
H
S
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
97
71.5
N.A.
78.1
34.3
N.A.
67.1
65
N.A.
65.6
N.A.
37.2
51
N.A.
43.5
Protein Similarity:
100
99.2
98.4
75.3
N.A.
84.8
46.5
N.A.
76.4
78.3
N.A.
76.9
N.A.
52.1
63.7
N.A.
59.9
P-Site Identity:
100
100
100
80
N.A.
73.3
6.6
N.A.
80
40
N.A.
13.3
N.A.
0
6.6
N.A.
46.6
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
6.6
N.A.
93.3
73.3
N.A.
20
N.A.
6.6
26.6
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
37.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
16
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
54
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
62
8
24
0
0
8
8
0
0
24
16
8
0
% D
% Glu:
0
8
8
47
31
0
8
8
16
0
16
16
8
0
0
% E
% Phe:
8
0
0
0
0
8
0
24
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
8
0
0
0
0
8
0
0
0
31
0
0
% G
% His:
8
0
0
0
8
8
8
0
0
0
0
8
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
0
8
16
8
% I
% Lys:
0
0
0
0
0
39
0
0
0
8
0
24
0
0
0
% K
% Leu:
54
0
8
0
0
8
0
8
0
0
0
0
24
0
70
% L
% Met:
0
0
8
0
0
0
0
0
0
16
8
0
0
0
0
% M
% Asn:
8
0
8
0
8
0
0
0
8
0
0
0
8
0
0
% N
% Pro:
0
16
0
16
8
0
24
8
62
8
62
8
0
0
0
% P
% Gln:
8
0
8
0
8
8
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% R
% Ser:
0
8
0
8
0
8
62
0
0
8
0
8
0
70
0
% S
% Thr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% T
% Val:
8
8
0
8
0
8
0
0
0
62
0
8
0
8
16
% V
% Trp:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
47
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _