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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: METTL2B All Species: 21.82
Human Site: Y247 Identified Species: 40
UniProt: Q6P1Q9 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6P1Q9 NP_060866.2 378 43440 Y247 L C D E E K S Y P V P K G S L
Chimpanzee Pan troglodytes XP_001152439 378 43448 Y247 L C D E E K S Y P V P K G S L
Rhesus Macaque Macaca mulatta XP_001116039 379 43675 Y248 L C D E E K S Y P V P K G S L
Dog Lupus familis XP_537604 474 53846 Y343 L C D E D K S Y P V P R D S L
Cat Felis silvestris
Mouse Mus musculus Q8BMK1 389 43893 Y240 L C D E D Q S Y P V P E D S L
Rat Rattus norvegicus Q6AXU8 287 33363 P165 F V L S A V H P E K M H L V L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518238 377 41950 Y246 L C D E H K S Y P M P E G S L
Chicken Gallus gallus Q5ZHP8 370 42711 F240 L C N D Q S P F P M P D E S L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio A8KBL7 353 40469 L231 Y P M P D H S L D V I V L I F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q86BS6 325 38113 E203 H W Q V P F E E N S Q D I I V
Honey Bee Apis mellifera XP_624474 332 39379 F210 Q E E W E T P F E P E S L D I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001175658 397 45417 F272 V S D P A A S F P V P D N S L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q08641 628 71467 D502 N P D G N L P D G V E P H S V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 97 71.5 N.A. 78.1 34.3 N.A. 67.1 65 N.A. 65.6 N.A. 37.2 51 N.A. 43.5
Protein Similarity: 100 99.2 98.4 75.3 N.A. 84.8 46.5 N.A. 76.4 78.3 N.A. 76.9 N.A. 52.1 63.7 N.A. 59.9
P-Site Identity: 100 100 100 80 N.A. 73.3 6.6 N.A. 80 40 N.A. 13.3 N.A. 0 6.6 N.A. 46.6
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 6.6 N.A. 93.3 73.3 N.A. 20 N.A. 6.6 26.6 N.A. 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 37.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 16 8 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 54 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 62 8 24 0 0 8 8 0 0 24 16 8 0 % D
% Glu: 0 8 8 47 31 0 8 8 16 0 16 16 8 0 0 % E
% Phe: 8 0 0 0 0 8 0 24 0 0 0 0 0 0 8 % F
% Gly: 0 0 0 8 0 0 0 0 8 0 0 0 31 0 0 % G
% His: 8 0 0 0 8 8 8 0 0 0 0 8 8 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 8 0 8 16 8 % I
% Lys: 0 0 0 0 0 39 0 0 0 8 0 24 0 0 0 % K
% Leu: 54 0 8 0 0 8 0 8 0 0 0 0 24 0 70 % L
% Met: 0 0 8 0 0 0 0 0 0 16 8 0 0 0 0 % M
% Asn: 8 0 8 0 8 0 0 0 8 0 0 0 8 0 0 % N
% Pro: 0 16 0 16 8 0 24 8 62 8 62 8 0 0 0 % P
% Gln: 8 0 8 0 8 8 0 0 0 0 8 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % R
% Ser: 0 8 0 8 0 8 62 0 0 8 0 8 0 70 0 % S
% Thr: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % T
% Val: 8 8 0 8 0 8 0 0 0 62 0 8 0 8 16 % V
% Trp: 0 8 0 8 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 47 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _