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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EDC4 All Species: 14.55
Human Site: S555 Identified Species: 32
UniProt: Q6P2E9 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6P2E9 NP_055144.3 1401 151661 S555 E S R P E L G S E G L G S A A
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001089684 1300 138998 S500 L G S E G L G S A A H G S Q P
Dog Lupus familis XP_546871 1484 160920 S640 E S R P E L G S E G L G S A P
Cat Felis silvestris
Mouse Mus musculus Q3UJB9 1406 152465 S555 E S R P E L G S E G L A S A A
Rat Rattus norvegicus Q3ZAV8 1407 152577 S555 E S R P E L G S E G L A S A P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_414022 1419 155974 A554 D H I A D L G A E G L G S E K
Frog Xenopus laevis Q7ZXT3 1391 153901 L542 P Q Q E N F A L P D I Q G I N
Zebra Danio Brachydanio rerio Q1LUT1 1384 151831 V549 D P L A D L N V E A M S S D K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VKK1 1354 149232 R560 R S S L N S K R S Q T P E D N
Honey Bee Apis mellifera XP_396550 1075 119372 T299 F F L D D H K T Y H P E V Q F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784386 1287 142473 N500 T T T S H G D N T L L D G L S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 63.8 90.1 N.A. 94.8 94.4 N.A. N.A. 74.3 62.4 61.6 N.A. 25.1 29.9 N.A. 32.9
Protein Similarity: 100 N.A. 70.2 91.5 N.A. 97 96.8 N.A. N.A. 84.9 78.5 77.4 N.A. 45.4 48.1 N.A. 50.6
P-Site Identity: 100 N.A. 33.3 93.3 N.A. 93.3 86.6 N.A. N.A. 46.6 0 20 N.A. 6.6 0 N.A. 6.6
P-Site Similarity: 100 N.A. 33.3 93.3 N.A. 93.3 86.6 N.A. N.A. 66.6 13.3 40 N.A. 6.6 13.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 19 0 0 10 10 10 19 0 19 0 37 19 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 19 0 0 10 28 0 10 0 0 10 0 10 0 19 0 % D
% Glu: 37 0 0 19 37 0 0 0 55 0 0 10 10 10 0 % E
% Phe: 10 10 0 0 0 10 0 0 0 0 0 0 0 0 10 % F
% Gly: 0 10 0 0 10 10 55 0 0 46 0 37 19 0 0 % G
% His: 0 10 0 0 10 10 0 0 0 10 10 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 0 10 0 0 10 0 % I
% Lys: 0 0 0 0 0 0 19 0 0 0 0 0 0 0 19 % K
% Leu: 10 0 19 10 0 64 0 10 0 10 55 0 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % M
% Asn: 0 0 0 0 19 0 10 10 0 0 0 0 0 0 19 % N
% Pro: 10 10 0 37 0 0 0 0 10 0 10 10 0 0 28 % P
% Gln: 0 10 10 0 0 0 0 0 0 10 0 10 0 19 0 % Q
% Arg: 10 0 37 0 0 0 0 10 0 0 0 0 0 0 0 % R
% Ser: 0 46 19 10 0 10 0 46 10 0 0 10 64 0 10 % S
% Thr: 10 10 10 0 0 0 0 10 10 0 10 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 10 0 0 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _