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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM53
All Species:
1.21
Human Site:
S25
Identified Species:
2.22
UniProt:
Q6P2H8
Number Species:
12
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P2H8
NP_078863.2
277
31630
S25
W
S
Q
K
N
S
P
S
P
G
G
K
E
A
E
Chimpanzee
Pan troglodytes
XP_513099
204
23435
Rhesus Macaque
Macaca mulatta
XP_001093396
204
23354
Dog
Lupus familis
XP_539639
278
31512
D25
R
S
Q
E
S
S
S
D
P
G
R
K
E
V
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9D0Z3
276
31570
G25
W
S
Q
K
N
R
Q
G
G
K
E
A
G
K
Q
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6DJC8
285
32654
E25
Q
G
C
P
W
D
P
E
R
E
P
V
V
I
L
Zebra Danio
Brachydanio rerio
Q6DHN0
281
32493
V30
R
G
S
K
E
P
V
V
I
L
L
G
W
A
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610178
343
39125
K66
K
N
E
F
V
L
A
K
D
H
D
G
E
D
S
Honey Bee
Apis mellifera
XP_392954
326
37186
E35
G
N
Q
D
Q
R
E
E
F
V
F
V
Y
K
E
Nematode Worm
Caenorhab. elegans
NP_491980
325
37453
V58
D
V
T
V
D
S
I
V
L
S
D
S
H
H
D
Sea Urchin
Strong. purpuratus
XP_788598
287
32857
S30
V
S
E
S
D
V
R
S
R
S
I
T
G
D
M
Poplar Tree
Populus trichocarpa
XP_002306371
443
48844
D161
I
D
V
S
G
S
S
D
C
L
S
E
K
S
R
Maize
Zea mays
NP_001146062
309
34480
D25
P
D
P
R
V
Y
A
D
F
P
D
K
S
Q
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
73.2
71.8
88.8
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
54
48
N.A.
30.8
30.3
24
33.1
Protein Similarity:
100
73.2
72.5
92.8
N.A.
91.6
N.A.
N.A.
N.A.
N.A.
68.4
65.1
N.A.
48.9
48.4
42.1
51.9
P-Site Identity:
100
0
0
46.6
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
6.6
13.3
N.A.
6.6
13.3
6.6
13.3
P-Site Similarity:
100
0
0
60
N.A.
40
N.A.
N.A.
N.A.
N.A.
6.6
13.3
N.A.
20
20
20
26.6
Percent
Protein Identity:
22.3
26.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
36.1
46.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
6.6
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
26.6
13.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
16
0
0
0
0
8
0
16
0
% A
% Cys:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
8
16
0
8
16
8
0
24
8
0
24
0
0
16
8
% D
% Glu:
0
0
16
8
8
0
8
16
0
8
8
8
24
0
16
% E
% Phe:
0
0
0
8
0
0
0
0
16
0
8
0
0
0
0
% F
% Gly:
8
16
0
0
8
0
0
8
8
16
8
16
16
0
16
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
8
8
0
% H
% Ile:
8
0
0
0
0
0
8
0
8
0
8
0
0
8
0
% I
% Lys:
8
0
0
24
0
0
0
8
0
8
0
24
8
16
0
% K
% Leu:
0
0
0
0
0
8
0
0
8
16
8
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
16
0
0
16
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
8
0
8
8
0
8
16
0
16
8
8
0
0
0
0
% P
% Gln:
8
0
31
0
8
0
8
0
0
0
0
0
0
8
8
% Q
% Arg:
16
0
0
8
0
16
8
0
16
0
8
0
0
0
8
% R
% Ser:
0
31
8
16
8
31
16
16
0
16
8
8
8
8
8
% S
% Thr:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
8
% T
% Val:
8
8
8
8
16
8
8
16
0
8
0
16
8
8
0
% V
% Trp:
16
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _