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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM53
All Species:
24.55
Human Site:
Y214
Identified Species:
45
UniProt:
Q6P2H8
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P2H8
NP_078863.2
277
31630
Y214
G
S
R
W
P
E
L
Y
L
Y
S
R
A
D
E
Chimpanzee
Pan troglodytes
XP_513099
204
23435
M158
L
A
R
D
I
E
R
M
V
E
A
R
L
A
R
Rhesus Macaque
Macaca mulatta
XP_001093396
204
23354
M158
P
A
R
D
V
E
R
M
V
E
A
R
L
A
R
Dog
Lupus familis
XP_539639
278
31512
Y215
A
S
R
W
P
E
L
Y
L
Y
S
R
A
D
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9D0Z3
276
31570
Y213
G
S
C
W
P
E
L
Y
L
Y
S
R
A
D
K
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6DJC8
285
32654
Y208
S
S
R
W
P
Q
L
Y
L
Y
S
R
A
D
P
Zebra Danio
Brachydanio rerio
Q6DHN0
281
32493
Y208
P
A
P
W
P
Q
M
Y
L
Y
S
R
A
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610178
343
39125
F257
A
N
R
Y
P
Q
L
F
L
Y
S
K
G
D
I
Honey Bee
Apis mellifera
XP_392954
326
37186
F222
S
Y
S
W
P
Q
L
F
L
Y
S
N
A
D
N
Nematode Worm
Caenorhab. elegans
NP_491980
325
37453
Y260
A
L
P
R
D
Q
L
Y
L
Y
S
K
A
D
T
Sea Urchin
Strong. purpuratus
XP_788598
287
32857
F222
K
M
Q
C
P
Q
L
F
L
Y
S
K
K
D
A
Poplar Tree
Populus trichocarpa
XP_002306371
443
48844
Y375
Q
P
S
C
P
Q
L
Y
I
Y
S
S
A
D
R
Maize
Zea mays
NP_001146062
309
34480
Y237
Q
P
K
C
P
Q
L
Y
I
Y
S
S
A
D
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
73.2
71.8
88.8
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
54
48
N.A.
30.8
30.3
24
33.1
Protein Similarity:
100
73.2
72.5
92.8
N.A.
91.6
N.A.
N.A.
N.A.
N.A.
68.4
65.1
N.A.
48.9
48.4
42.1
51.9
P-Site Identity:
100
20
20
93.3
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
80
60
N.A.
46.6
53.3
46.6
40
P-Site Similarity:
100
40
40
93.3
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
86.6
80
N.A.
80
66.6
60
66.6
Percent
Protein Identity:
22.3
26.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
36.1
46.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
46.6
46.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
60
66.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
24
0
0
0
0
0
0
0
0
16
0
70
16
8
% A
% Cys:
0
0
8
24
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
16
8
0
0
0
0
0
0
0
0
85
0
% D
% Glu:
0
0
0
0
0
39
0
0
0
16
0
0
0
0
16
% E
% Phe:
0
0
0
0
0
0
0
24
0
0
0
0
0
0
0
% F
% Gly:
16
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
16
0
0
0
0
0
8
% I
% Lys:
8
0
8
0
0
0
0
0
0
0
0
24
8
0
8
% K
% Leu:
8
8
0
0
0
0
77
0
70
0
0
0
16
0
0
% L
% Met:
0
8
0
0
0
0
8
16
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
8
% N
% Pro:
16
16
16
0
77
0
0
0
0
0
0
0
0
0
8
% P
% Gln:
16
0
8
0
0
62
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
47
8
0
0
16
0
0
0
0
54
0
0
39
% R
% Ser:
16
31
16
0
0
0
0
0
0
0
85
16
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% T
% Val:
0
0
0
0
8
0
0
0
16
0
0
0
0
0
0
% V
% Trp:
0
0
0
47
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
8
0
0
0
62
0
85
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _