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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM53
All Species:
13.03
Human Site:
Y259
Identified Species:
23.89
UniProt:
Q6P2H8
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P2H8
NP_078863.2
277
31630
Y259
H
V
S
H
L
R
D
Y
P
T
Y
Y
T
S
L
Chimpanzee
Pan troglodytes
XP_513099
204
23435
T191
R
D
Y
P
T
Y
Y
T
S
L
C
V
D
F
M
Rhesus Macaque
Macaca mulatta
XP_001093396
204
23354
T191
R
D
Y
P
T
Y
Y
T
S
L
C
V
D
F
M
Dog
Lupus familis
XP_539639
278
31512
Y260
H
V
S
H
L
R
D
Y
P
T
Y
Y
T
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9D0Z3
276
31570
Y258
H
V
S
H
L
R
D
Y
P
T
Y
Y
T
S
L
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6DJC8
285
32654
F253
H
V
S
H
F
R
R
F
P
H
R
Y
S
E
M
Zebra Danio
Brachydanio rerio
Q6DHN0
281
32493
C253
H
V
S
L
F
R
D
C
P
E
D
Y
S
N
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610178
343
39125
Y302
H
V
K
I
Y
T
K
Y
P
K
Q
Y
V
Q
C
Honey Bee
Apis mellifera
XP_392954
326
37186
Y267
H
V
K
H
Y
A
T
Y
R
D
A
Y
V
N
T
Nematode Worm
Caenorhab. elegans
NP_491980
325
37453
H305
H
V
A
H
I
R
T
H
P
K
D
Y
R
T
A
Sea Urchin
Strong. purpuratus
XP_788598
287
32857
H267
H
V
A
H
L
R
K
H
P
E
E
Y
V
A
A
Poplar Tree
Populus trichocarpa
XP_002306371
443
48844
D420
H
V
D
H
F
R
N
D
P
K
L
Y
T
T
Q
Maize
Zea mays
NP_001146062
309
34480
N282
H
V
D
H
Y
R
S
N
P
G
L
Y
S
S
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
73.2
71.8
88.8
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
54
48
N.A.
30.8
30.3
24
33.1
Protein Similarity:
100
73.2
72.5
92.8
N.A.
91.6
N.A.
N.A.
N.A.
N.A.
68.4
65.1
N.A.
48.9
48.4
42.1
51.9
P-Site Identity:
100
0
0
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
46.6
46.6
N.A.
33.3
33.3
40
46.6
P-Site Similarity:
100
6.6
6.6
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
66.6
60
N.A.
33.3
40
66.6
66.6
Percent
Protein Identity:
22.3
26.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
36.1
46.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
46.6
46.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
60
53.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
16
0
0
8
0
0
0
0
8
0
0
8
16
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
16
0
0
0
8
% C
% Asp:
0
16
16
0
0
0
31
8
0
8
16
0
16
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
16
8
0
0
8
0
% E
% Phe:
0
0
0
0
24
0
0
8
0
0
0
0
0
16
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% G
% His:
85
0
0
70
0
0
0
16
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
16
0
0
0
16
0
0
24
0
0
0
0
0
% K
% Leu:
0
0
0
8
31
0
0
0
0
16
16
0
0
0
24
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
24
% M
% Asn:
0
0
0
0
0
0
8
8
0
0
0
0
0
16
0
% N
% Pro:
0
0
0
16
0
0
0
0
77
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
16
% Q
% Arg:
16
0
0
0
0
70
8
0
8
0
8
0
8
0
8
% R
% Ser:
0
0
39
0
0
0
8
0
16
0
0
0
24
31
0
% S
% Thr:
0
0
0
0
16
8
16
16
0
24
0
0
31
16
8
% T
% Val:
0
85
0
0
0
0
0
0
0
0
0
16
24
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
16
0
24
16
16
39
0
0
24
85
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _