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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM53
All Species:
24.55
Human Site:
Y58
Identified Species:
45
UniProt:
Q6P2H8
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P2H8
NP_078863.2
277
31630
Y58
L
A
K
Y
S
A
I
Y
H
K
R
G
C
I
V
Chimpanzee
Pan troglodytes
XP_513099
204
23435
E30
L
L
F
D
Y
E
I
E
K
E
P
L
L
F
H
Rhesus Macaque
Macaca mulatta
XP_001093396
204
23354
E30
L
L
F
D
Y
E
I
E
K
E
P
L
L
F
H
Dog
Lupus familis
XP_539639
278
31512
Y58
L
A
K
Y
S
A
I
Y
H
K
R
G
C
I
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9D0Z3
276
31570
Y56
L
A
K
Y
S
A
I
Y
H
K
R
G
C
I
V
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6DJC8
285
32654
E80
L
G
F
S
S
L
R
E
D
A
K
K
L
L
E
Zebra Danio
Brachydanio rerio
Q6DHN0
281
32493
S80
L
G
Y
K
E
L
R
S
T
A
H
K
L
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610178
343
39125
Y98
L
M
K
Y
S
K
I
Y
E
E
R
G
L
I
T
Honey Bee
Apis mellifera
XP_392954
326
37186
Y68
L
A
K
Y
S
A
I
Y
E
E
K
S
C
I
T
Nematode Worm
Caenorhab. elegans
NP_491980
325
37453
N92
D
K
Y
I
K
V
Y
N
D
E
G
Y
R
V
V
Sea Urchin
Strong. purpuratus
XP_788598
287
32857
Y63
L
A
K
Y
S
S
I
Y
Q
S
K
G
F
I
T
Poplar Tree
Populus trichocarpa
XP_002306371
443
48844
Y191
L
K
K
Y
A
E
W
Y
T
S
R
G
F
H
V
Maize
Zea mays
NP_001146062
309
34480
Y54
L
K
R
Y
A
D
W
Y
T
S
R
G
F
H
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
73.2
71.8
88.8
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
54
48
N.A.
30.8
30.3
24
33.1
Protein Similarity:
100
73.2
72.5
92.8
N.A.
91.6
N.A.
N.A.
N.A.
N.A.
68.4
65.1
N.A.
48.9
48.4
42.1
51.9
P-Site Identity:
100
13.3
13.3
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
13.3
6.6
N.A.
60
66.6
6.6
60
P-Site Similarity:
100
20
20
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
26.6
13.3
N.A.
66.6
80
20
73.3
Percent
Protein Identity:
22.3
26.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
36.1
46.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
46.6
40
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
53.3
53.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
39
0
0
16
31
0
0
0
16
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
31
0
0
% C
% Asp:
8
0
0
16
0
8
0
0
16
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
8
24
0
24
16
39
0
0
0
0
16
% E
% Phe:
0
0
24
0
0
0
0
0
0
0
0
0
24
16
0
% F
% Gly:
0
16
0
0
0
0
0
0
0
0
8
54
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
24
0
8
0
0
16
16
% H
% Ile:
0
0
0
8
0
0
62
0
0
0
0
0
0
47
0
% I
% Lys:
0
24
54
8
8
8
0
0
16
24
24
16
0
0
0
% K
% Leu:
93
16
0
0
0
16
0
0
0
0
0
16
39
16
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
8
0
0
0
16
0
0
0
47
0
8
0
0
% R
% Ser:
0
0
0
8
54
8
0
8
0
24
0
8
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
24
0
0
0
0
0
24
% T
% Val:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
47
% V
% Trp:
0
0
0
0
0
0
16
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
16
62
16
0
8
62
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _