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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF8
All Species:
18.48
Human Site:
S2327
Identified Species:
33.89
UniProt:
Q6P2Q9
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P2Q9
NP_006436.3
2335
273600
S2327
L
Q
E
G
E
V
Y
S
A
D
R
E
D
L
Y
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001117328
2324
271913
Y2317
Y
D
W
T
G
A
V
Y
S
K
M
L
G
S
L
Dog
Lupus familis
XP_868467
2335
273550
S2327
L
Q
E
G
E
V
Y
S
A
D
R
E
D
L
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q99PV0
2335
273598
S2327
L
Q
E
G
E
V
Y
S
A
D
R
E
D
L
Y
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415805
2335
273614
S2327
L
Q
E
G
E
V
Y
S
A
D
R
E
D
L
Y
Frog
Xenopus laevis
NP_001080253
2335
273603
S2327
L
Q
E
G
E
V
Y
S
A
D
R
E
D
L
Y
Zebra Danio
Brachydanio rerio
NP_957270
2342
274356
N2334
L
Q
E
G
E
I
Y
N
A
D
R
E
D
M
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610735
2396
279559
A2387
L
E
D
G
G
D
G
A
G
A
D
R
E
D
V
Honey Bee
Apis mellifera
XP_624014
2374
277137
G2366
L
E
D
G
E
G
V
G
A
D
R
E
D
V
F
Nematode Worm
Caenorhab. elegans
P34369
2329
272009
G2320
F
D
D
P
L
G
T
G
S
A
D
R
E
D
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002327417
2357
275373
E2349
L
E
E
G
E
T
A
E
G
D
R
E
D
T
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_178124
2382
278110
E2374
M
E
E
A
D
I
T
E
G
D
R
E
D
T
F
Baker's Yeast
Sacchar. cerevisiae
P33334
2413
279485
E2405
L
A
G
D
E
E
L
E
A
E
Q
I
D
V
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.1
99.7
N.A.
99.9
N.A.
N.A.
N.A.
99.4
98.5
97.6
N.A.
89.4
90.4
86.5
N.A.
Protein Similarity:
100
N.A.
98.5
99.8
N.A.
99.9
N.A.
N.A.
N.A.
99.6
99.4
99
N.A.
94.1
95.2
94.3
N.A.
P-Site Identity:
100
N.A.
0
100
N.A.
100
N.A.
N.A.
N.A.
100
100
80
N.A.
13.3
53.3
0
N.A.
P-Site Similarity:
100
N.A.
6.6
100
N.A.
100
N.A.
N.A.
N.A.
100
100
100
N.A.
40
80
20
N.A.
Percent
Protein Identity:
82.4
N.A.
N.A.
81.4
60.6
N.A.
Protein Similarity:
91.3
N.A.
N.A.
90.6
75.7
N.A.
P-Site Identity:
53.3
N.A.
N.A.
33.3
26.6
N.A.
P-Site Similarity:
66.6
N.A.
N.A.
66.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
0
8
8
8
62
16
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
16
24
8
8
8
0
0
0
70
16
0
77
16
0
% D
% Glu:
0
31
62
0
70
8
0
24
0
8
0
70
16
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
31
% F
% Gly:
0
0
8
70
16
16
8
16
24
0
0
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
16
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% K
% Leu:
77
0
0
0
8
0
8
0
0
0
0
8
0
39
8
% L
% Met:
8
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
47
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
70
16
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
39
16
0
0
0
0
8
0
% S
% Thr:
0
0
0
8
0
8
16
0
0
0
0
0
0
16
0
% T
% Val:
0
0
0
0
0
39
16
0
0
0
0
0
0
16
8
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
47
8
0
0
0
0
0
0
47
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _