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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF8
All Species:
36.97
Human Site:
Y318
Identified Species:
67.78
UniProt:
Q6P2Q9
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P2Q9
NP_006436.3
2335
273600
Y318
E
Y
K
I
A
F
P
Y
L
Y
N
N
L
P
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001117328
2324
271913
Y318
E
Y
K
I
A
F
P
Y
L
Y
N
N
L
P
H
Dog
Lupus familis
XP_868467
2335
273550
Y318
E
Y
K
I
A
F
P
Y
L
Y
N
N
L
P
H
Cat
Felis silvestris
Mouse
Mus musculus
Q99PV0
2335
273598
Y318
E
Y
K
I
A
F
P
Y
L
Y
N
N
L
P
H
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415805
2335
273614
Y318
E
Y
K
I
A
F
P
Y
L
Y
N
N
L
P
H
Frog
Xenopus laevis
NP_001080253
2335
273603
Y318
E
Y
K
I
A
F
P
Y
L
Y
N
N
L
P
H
Zebra Danio
Brachydanio rerio
NP_957270
2342
274356
Y325
E
Y
K
I
A
F
P
Y
L
Y
N
N
L
P
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610735
2396
279559
Y377
E
Y
R
I
A
F
P
Y
L
Y
N
N
M
P
H
Honey Bee
Apis mellifera
XP_624014
2374
277137
Y357
E
Y
R
I
A
F
P
Y
L
Y
N
N
M
P
H
Nematode Worm
Caenorhab. elegans
P34369
2329
272009
Y308
R
I
A
F
P
F
M
Y
N
N
L
I
S
S
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002327417
2357
275373
H336
E
Y
R
I
A
F
P
H
L
Y
N
N
R
P
R
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_178124
2382
278110
H364
E
Y
R
I
A
F
P
H
L
Y
N
N
R
P
R
Baker's Yeast
Sacchar. cerevisiae
P33334
2413
279485
H389
E
Y
K
V
A
F
P
H
L
Y
N
S
R
P
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.1
99.7
N.A.
99.9
N.A.
N.A.
N.A.
99.4
98.5
97.6
N.A.
89.4
90.4
86.5
N.A.
Protein Similarity:
100
N.A.
98.5
99.8
N.A.
99.9
N.A.
N.A.
N.A.
99.6
99.4
99
N.A.
94.1
95.2
94.3
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
N.A.
100
100
100
N.A.
86.6
86.6
13.3
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
N.A.
100
100
100
N.A.
100
100
13.3
N.A.
Percent
Protein Identity:
82.4
N.A.
N.A.
81.4
60.6
N.A.
Protein Similarity:
91.3
N.A.
N.A.
90.6
75.7
N.A.
P-Site Identity:
73.3
N.A.
N.A.
73.3
66.6
N.A.
P-Site Similarity:
86.6
N.A.
N.A.
86.6
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
93
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
93
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
8
0
100
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
24
0
0
0
0
0
0
70
% H
% Ile:
0
8
0
85
0
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
62
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
93
0
8
0
54
0
8
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
16
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
8
93
85
0
0
0
% N
% Pro:
0
0
0
0
8
0
93
0
0
0
0
0
0
93
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
31
0
0
0
0
0
0
0
0
0
24
0
24
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
8
8
8
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
93
0
0
0
0
0
77
0
93
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _