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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CASC4
All Species:
16.97
Human Site:
T338
Identified Species:
41.48
UniProt:
Q6P4E1
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P4E1
NP_816929.1
433
48864
T338
D
S
E
P
R
I
Q
T
D
I
L
K
Q
A
T
Chimpanzee
Pan troglodytes
XP_001161398
436
49465
T338
D
S
E
P
R
I
Q
T
D
I
L
K
Q
A
T
Rhesus Macaque
Macaca mulatta
XP_001110185
433
48793
T338
D
S
E
P
R
I
Q
T
D
I
L
K
Q
A
T
Dog
Lupus familis
XP_850044
433
48642
A338
E
S
V
P
R
I
Q
A
D
I
L
K
Q
A
T
Cat
Felis silvestris
Mouse
Mus musculus
Q6P2L7
435
49390
T337
D
R
E
P
R
I
Q
T
D
T
L
K
Q
A
T
Rat
Rattus norvegicus
XP_001077018
436
49523
T338
E
R
E
P
R
I
Q
T
D
T
I
K
Q
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516168
286
32689
L202
A
Q
P
P
F
W
K
L
N
L
E
S
G
T
Y
Chicken
Gallus gallus
Q5ZKQ5
375
42479
H287
N
L
P
T
E
Q
P
H
A
P
N
L
A
P
G
Frog
Xenopus laevis
Q32N32
385
43955
V300
L
P
D
K
K
E
T
V
Q
I
P
E
V
E
E
Zebra Danio
Brachydanio rerio
XP_683317
439
49408
A286
K
H
M
E
P
A
E
A
A
A
M
L
K
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94
97.4
90.9
N.A.
85.5
85
N.A.
44.3
51.5
45.7
35.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
94.9
98.8
94.6
N.A.
89.8
89.2
N.A.
55.2
66
60.5
56
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
86.6
73.3
N.A.
6.6
0
6.6
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
26.6
6.6
26.6
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
10
0
20
20
10
0
0
10
60
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
40
0
10
0
0
0
0
0
60
0
0
0
0
0
0
% D
% Glu:
20
0
50
10
10
10
10
0
0
0
10
10
0
20
20
% E
% Phe:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
10
% G
% His:
0
10
0
0
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
60
0
0
0
50
10
0
0
0
0
% I
% Lys:
10
0
0
10
10
0
10
0
0
0
0
60
10
0
0
% K
% Leu:
10
10
0
0
0
0
0
10
0
10
50
20
0
0
0
% L
% Met:
0
0
10
0
0
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% N
% Pro:
0
10
20
70
10
0
10
0
0
10
10
0
0
10
0
% P
% Gln:
0
10
0
0
0
10
60
0
10
0
0
0
60
0
0
% Q
% Arg:
0
20
0
0
60
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
40
0
0
0
0
0
0
0
0
0
10
0
0
0
% S
% Thr:
0
0
0
10
0
0
10
50
0
20
0
0
0
10
60
% T
% Val:
0
0
10
0
0
0
0
10
0
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _