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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PKN3 All Species: 18.79
Human Site: S469 Identified Species: 29.52
UniProt: Q6P5Z2 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6P5Z2 NP_037487.2 889 99421 S469 L P P C S S P S T I S P P K G
Chimpanzee Pan troglodytes XP_001159776 886 99121 S466 L P P C S S P S T I S P P K G
Rhesus Macaque Macaca mulatta XP_001110500 1011 111864 S582 L P P C S S P S T I S P P K G
Dog Lupus familis XP_548434 951 104664 S531 L P P C S S P S T I S P P K A
Cat Felis silvestris
Mouse Mus musculus Q8K045 878 97863 C458 V M S L L P P C S S P N T A S
Rat Rattus norvegicus O08874 985 112050 G533 I P T V N H S G T F S P Q T P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506565 993 109767 G567 L G L L P P C G S P S S T L S
Chicken Gallus gallus XP_422357 1013 114806 P605 P E P P P A P P R A S S L G E
Frog Xenopus laevis Q7ZX15 486 56292 S137 G S P S D V S S A E Q M D V A
Zebra Danio Brachydanio rerio XP_697542 940 106140 T521 P P C N S T I T A L S P P L P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P13678 634 71138 G285 S L A V T G S G G V G A T G E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34885 707 80133 N345 S G S S N S E N S G Y L Q Q I
Sea Urchin Strong. purpuratus XP_787090 799 90414 S358 I P S S L T P S G T S P P T A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P24583 1151 131500 P588 L A E R A N A P L P P Q P R K
Red Bread Mold Neurospora crassa P87253 1142 127954 Q715 D D E Y S A Q Q Q Q G Y G S P
Conservation
Percent
Protein Identity: 100 97.7 81.5 84.2 N.A. 83.2 49.9 N.A. 64.2 48.9 26.2 52.2 N.A. 28 N.A. 29.1 41.5
Protein Similarity: 100 97.8 82.9 87.6 N.A. 88.4 63.6 N.A. 72.9 63 36.6 67.6 N.A. 41.5 N.A. 43.9 58.2
P-Site Identity: 100 100 100 93.3 N.A. 6.6 26.6 N.A. 13.3 20 13.3 33.3 N.A. 0 N.A. 6.6 40
P-Site Similarity: 100 100 100 93.3 N.A. 20 40 N.A. 20 26.6 13.3 53.3 N.A. 13.3 N.A. 33.3 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 25.2 27.1
Protein Similarity: N.A. N.A. N.A. N.A. 41.7 43.2
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 7 14 7 0 14 7 0 7 0 7 20 % A
% Cys: 0 0 7 27 0 0 7 7 0 0 0 0 0 0 0 % C
% Asp: 7 7 0 0 7 0 0 0 0 0 0 0 7 0 0 % D
% Glu: 0 7 14 0 0 0 7 0 0 7 0 0 0 0 14 % E
% Phe: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % F
% Gly: 7 14 0 0 0 7 0 20 14 7 14 0 7 14 20 % G
% His: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % H
% Ile: 14 0 0 0 0 0 7 0 0 27 0 0 0 0 7 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 27 7 % K
% Leu: 40 7 7 14 14 0 0 0 7 7 0 7 7 14 0 % L
% Met: 0 7 0 0 0 0 0 0 0 0 0 7 0 0 0 % M
% Asn: 0 0 0 7 14 7 0 7 0 0 0 7 0 0 0 % N
% Pro: 14 47 40 7 14 14 47 14 0 14 14 47 47 0 20 % P
% Gln: 0 0 0 0 0 0 7 7 7 7 7 7 14 7 0 % Q
% Arg: 0 0 0 7 0 0 0 0 7 0 0 0 0 7 0 % R
% Ser: 14 7 20 20 40 34 20 40 20 7 60 14 0 7 14 % S
% Thr: 0 0 7 0 7 14 0 7 34 7 0 0 20 14 0 % T
% Val: 7 0 0 14 0 7 0 0 0 7 0 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 0 7 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _