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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PKN3 All Species: 16.67
Human Site: S494 Identified Species: 26.19
UniProt: Q6P5Z2 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6P5Z2 NP_037487.2 889 99421 S494 A S D P A T P S N F L P K K T
Chimpanzee Pan troglodytes XP_001159776 886 99121 S491 A S D P A T P S N F L P K K T
Rhesus Macaque Macaca mulatta XP_001110500 1011 111864 S607 A S D P A T P S N F L P K K T
Dog Lupus familis XP_548434 951 104664 S556 A A E P A S P S N V P P K K S
Cat Felis silvestris
Mouse Mus musculus Q8K045 878 97863 S483 C G T P S A A S P S N F L P M
Rat Rattus norvegicus O08874 985 112050 P558 R T P E L A P P A S D S T V T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506565 993 109767 P592 A A R V A S A P A S A S P F P
Chicken Gallus gallus XP_422357 1013 114806 D630 P D M P A Q D D V S T F D F E
Frog Xenopus laevis Q7ZX15 486 56292 L162 N D F D Y L K L L G K G T F G
Zebra Danio Brachydanio rerio XP_697542 940 106140 D546 S T P P S T G D S A V V K L N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P13678 634 71138 G310 F N F I K V L G K G S F G K V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34885 707 80133 G370 R S A S K V P G G T L S I H D
Sea Urchin Strong. purpuratus XP_787090 799 90414 S383 S F G E A D S S E S A G S N S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P24583 1151 131500 Q613 G R D S P T K Q H D P I I D K
Red Bread Mold Neurospora crassa P87253 1142 127954 S740 A N I D A Y S S P Q A R P Q Q
Conservation
Percent
Protein Identity: 100 97.7 81.5 84.2 N.A. 83.2 49.9 N.A. 64.2 48.9 26.2 52.2 N.A. 28 N.A. 29.1 41.5
Protein Similarity: 100 97.8 82.9 87.6 N.A. 88.4 63.6 N.A. 72.9 63 36.6 67.6 N.A. 41.5 N.A. 43.9 58.2
P-Site Identity: 100 100 100 60 N.A. 13.3 13.3 N.A. 13.3 13.3 0 20 N.A. 6.6 N.A. 20 13.3
P-Site Similarity: 100 100 100 86.6 N.A. 20 20 N.A. 26.6 13.3 0 53.3 N.A. 13.3 N.A. 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 25.2 27.1
Protein Similarity: N.A. N.A. N.A. N.A. 41.7 43.2
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 20
P-Site Similarity: N.A. N.A. N.A. N.A. 20 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 40 14 7 0 54 14 14 0 14 7 20 0 0 0 0 % A
% Cys: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 14 27 14 0 7 7 14 0 7 7 0 7 7 7 % D
% Glu: 0 0 7 14 0 0 0 0 7 0 0 0 0 0 7 % E
% Phe: 7 7 14 0 0 0 0 0 0 20 0 20 0 20 0 % F
% Gly: 7 7 7 0 0 0 7 14 7 14 0 14 7 0 7 % G
% His: 0 0 0 0 0 0 0 0 7 0 0 0 0 7 0 % H
% Ile: 0 0 7 7 0 0 0 0 0 0 0 7 14 0 0 % I
% Lys: 0 0 0 0 14 0 14 0 7 0 7 0 34 34 7 % K
% Leu: 0 0 0 0 7 7 7 7 7 0 27 0 7 7 0 % L
% Met: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 7 14 0 0 0 0 0 0 27 0 7 0 0 7 7 % N
% Pro: 7 0 14 47 7 0 40 14 14 0 14 27 14 7 7 % P
% Gln: 0 0 0 0 0 7 0 7 0 7 0 0 0 7 7 % Q
% Arg: 14 7 7 0 0 0 0 0 0 0 0 7 0 0 0 % R
% Ser: 14 27 0 14 14 14 14 47 7 34 7 20 7 0 14 % S
% Thr: 0 14 7 0 0 34 0 0 0 7 7 0 14 0 27 % T
% Val: 0 0 0 7 0 14 0 0 7 7 7 7 0 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 7 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _