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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HISPPD2A All Species: 22.73
Human Site: S230 Identified Species: 41.67
UniProt: Q6PFW1 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6PFW1 NP_001019634.1 1433 159521 S230 F R K I G S R S S V Y S P E S
Chimpanzee Pan troglodytes XP_510352 1408 156588 S230 F R K I G S R S S V Y S P E S
Rhesus Macaque Macaca mulatta XP_001098229 1243 140375 G104 L I S F H S K G F P L D K A V
Dog Lupus familis XP_535450 1457 162086 S230 F R K I G S R S S V Y S P E S
Cat Felis silvestris
Mouse Mus musculus A2ARP1 1436 159904 S230 F R K I G S R S S V Y S P E S
Rat Rattus norvegicus P0C644 1434 159600 S232 F R K I G S R S S V Y S P E S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505793 1285 145199 I146 V I F E E D V I L N E P V E N
Chicken Gallus gallus XP_413955 1359 152194 N206 P V S A E D H N V Y I Y Y P T
Frog Xenopus laevis Q5XHF8 1131 128702
Zebra Danio Brachydanio rerio XP_684718 1352 151299 N207 P V S A E D H N V Y I Y Y P T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VR59 1696 188659 S242 F R K I G S R S S V Y S P E S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P91309 1323 150102 Q184 S S V G G G S Q R L F R K I N
Sea Urchin Strong. purpuratus XP_001194114 1337 149934 G193 Y P S S A G G G S Q R L F R K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.6 57.5 90.1 N.A. 90.1 89.2 N.A. 58.9 70.2 57.8 68.8 N.A. 44.1 N.A. 39.7 47.7
Protein Similarity: 100 97.9 67.8 92.5 N.A. 93.3 92.4 N.A. 69.7 79.6 66.9 78.1 N.A. 57.7 N.A. 56.3 62.5
P-Site Identity: 100 100 6.6 100 N.A. 100 100 N.A. 6.6 0 0 0 N.A. 100 N.A. 6.6 6.6
P-Site Similarity: 100 100 13.3 100 N.A. 100 100 N.A. 13.3 13.3 0 13.3 N.A. 100 N.A. 26.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 16 8 0 0 0 0 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 24 0 0 0 0 0 8 0 0 0 % D
% Glu: 0 0 0 8 24 0 0 0 0 0 8 0 0 54 0 % E
% Phe: 47 0 8 8 0 0 0 0 8 0 8 0 8 0 0 % F
% Gly: 0 0 0 8 54 16 8 16 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 8 0 16 0 0 0 0 0 0 0 0 % H
% Ile: 0 16 0 47 0 0 0 8 0 0 16 0 0 8 0 % I
% Lys: 0 0 47 0 0 0 8 0 0 0 0 0 16 0 8 % K
% Leu: 8 0 0 0 0 0 0 0 8 8 8 8 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 16 0 8 0 0 0 0 16 % N
% Pro: 16 8 0 0 0 0 0 0 0 8 0 8 47 16 0 % P
% Gln: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % Q
% Arg: 0 47 0 0 0 0 47 0 8 0 8 8 0 8 0 % R
% Ser: 8 8 31 8 0 54 8 47 54 0 0 47 0 0 47 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16 % T
% Val: 8 16 8 0 0 0 8 0 16 47 0 0 8 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 16 47 16 16 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _