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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HISPPD2A All Species: 22.73
Human Site: Y575 Identified Species: 41.67
UniProt: Q6PFW1 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6PFW1 NP_001019634.1 1433 159521 Y575 F R H D L K I Y A S D E G R V
Chimpanzee Pan troglodytes XP_510352 1408 156588 Y575 F R H D L K I Y A S D E G R V
Rhesus Macaque Macaca mulatta XP_001098229 1243 140375 K426 S G K L K L K K P K Q L Q E V
Dog Lupus familis XP_535450 1457 162086 Y575 F R H D L K I Y A S D E G R V
Cat Felis silvestris
Mouse Mus musculus A2ARP1 1436 159904 Y575 F R H D L K I Y A S D E G R V
Rat Rattus norvegicus P0C644 1434 159600 Y577 F R H D L K I Y A S D E G R V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505793 1285 145199 Q468 M K M E V R H Q K F F D L F E
Chicken Gallus gallus XP_413955 1359 152194 Q534 L T P A G R V Q A E E L G R A
Frog Xenopus laevis Q5XHF8 1131 128702 A314 I A W K V C L A F K Q T V C G
Zebra Danio Brachydanio rerio XP_684718 1352 151299 G531 G G E L T P A G R V Q A E E L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VR59 1696 188659 Y592 F R H D L K I Y A S D E G R V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P91309 1323 150102 G506 D E E L R R E G P A L L L I L
Sea Urchin Strong. purpuratus XP_001194114 1337 149934 F515 A E E L G R A F R C I Y P G G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.6 57.5 90.1 N.A. 90.1 89.2 N.A. 58.9 70.2 57.8 68.8 N.A. 44.1 N.A. 39.7 47.7
Protein Similarity: 100 97.9 67.8 92.5 N.A. 93.3 92.4 N.A. 69.7 79.6 66.9 78.1 N.A. 57.7 N.A. 56.3 62.5
P-Site Identity: 100 100 6.6 100 N.A. 100 100 N.A. 0 20 0 0 N.A. 100 N.A. 0 0
P-Site Similarity: 100 100 6.6 100 N.A. 100 100 N.A. 33.3 40 13.3 6.6 N.A. 100 N.A. 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 8 0 0 16 8 54 8 0 8 0 0 8 % A
% Cys: 0 0 0 0 0 8 0 0 0 8 0 0 0 8 0 % C
% Asp: 8 0 0 47 0 0 0 0 0 0 47 8 0 0 0 % D
% Glu: 0 16 24 8 0 0 8 0 0 8 8 47 8 16 8 % E
% Phe: 47 0 0 0 0 0 0 8 8 8 8 0 0 8 0 % F
% Gly: 8 16 0 0 16 0 0 16 0 0 0 0 54 8 16 % G
% His: 0 0 47 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 0 47 0 0 0 8 0 0 8 0 % I
% Lys: 0 8 8 8 8 47 8 8 8 16 0 0 0 0 0 % K
% Leu: 8 0 0 31 47 8 8 0 0 0 8 24 16 0 16 % L
% Met: 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 8 0 0 8 0 0 16 0 0 0 8 0 0 % P
% Gln: 0 0 0 0 0 0 0 16 0 0 24 0 8 0 0 % Q
% Arg: 0 47 0 0 8 31 0 0 16 0 0 0 0 54 0 % R
% Ser: 8 0 0 0 0 0 0 0 0 47 0 0 0 0 0 % S
% Thr: 0 8 0 0 8 0 0 0 0 0 0 8 0 0 0 % T
% Val: 0 0 0 0 16 0 8 0 0 8 0 0 8 0 54 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 47 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _