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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HDMCP All Species: 22.12
Human Site: S265 Identified Species: 40.56
UniProt: Q6Q0C1 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6Q0C1 NP_997000.2 308 33435 S265 L L H C M V T S V R E E G P R
Chimpanzee Pan troglodytes XP_001159368 308 33445 S265 L L H C M V T S V R E E G P R
Rhesus Macaque Macaca mulatta XP_001113849 288 31847 S249 V L D C M V S S V R Q E G L G
Dog Lupus familis XP_855336 388 41936 N345 L L H C V V T N V R E E G P R
Cat Felis silvestris
Mouse Mus musculus Q6IS41 310 33627 S267 L L H C V V T S V R E E G P R
Rat Rattus norvegicus Q6J329 310 33599 S267 L L H C V V T S V R E E G P R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512948 482 52245 S439 L V H C V A A S V R E E G V G
Chicken Gallus gallus XP_421367 330 35816 G297 G L K V L F K G L G L N C I R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio A4QNX2 288 31518 L258 R T E G S G V L F R G L T V N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VQG4 306 32934 I262 R S V F K D L I V K D G P L A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q27257 312 33116 L253 R G V L R E V L R E E G P R A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q93XM7 300 31004 I261 S M D A F R K I L K S E G V K
Baker's Yeast Sacchar. cerevisiae P32331 307 33357 T267 S I S S V A K T L Y A N G G I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.7 43.1 68.5 N.A. 87.7 86.4 N.A. 37.7 54.8 N.A. 52.9 N.A. 20.4 N.A. 33.3 N.A.
Protein Similarity: 100 98.3 62 71.6 N.A. 91.2 90.6 N.A. 47.2 68.1 N.A. 66.2 N.A. 35.3 N.A. 48 N.A.
P-Site Identity: 100 100 60 86.6 N.A. 93.3 93.3 N.A. 60 13.3 N.A. 6.6 N.A. 6.6 N.A. 6.6 N.A.
P-Site Similarity: 100 100 80 100 N.A. 100 100 N.A. 73.3 26.6 N.A. 6.6 N.A. 20 N.A. 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 33.7 21.1 N.A.
Protein Similarity: N.A. N.A. N.A. 47.7 38.6 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 16 8 0 0 0 8 0 0 0 16 % A
% Cys: 0 0 0 54 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 16 0 0 8 0 0 0 0 8 0 0 0 0 % D
% Glu: 0 0 8 0 0 8 0 0 0 8 54 62 0 0 0 % E
% Phe: 0 0 0 8 8 8 0 0 8 0 0 0 0 0 0 % F
% Gly: 8 8 0 8 0 8 0 8 0 8 8 16 70 8 16 % G
% His: 0 0 47 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 16 0 0 0 0 0 8 8 % I
% Lys: 0 0 8 0 8 0 24 0 0 16 0 0 0 0 8 % K
% Leu: 47 54 0 8 8 0 8 16 24 0 8 8 0 16 0 % L
% Met: 0 8 0 0 24 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 8 0 0 0 16 0 0 8 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 16 39 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % Q
% Arg: 24 0 0 0 8 8 0 0 8 62 0 0 0 8 47 % R
% Ser: 16 8 8 8 8 0 8 47 0 0 8 0 0 0 0 % S
% Thr: 0 8 0 0 0 0 39 8 0 0 0 0 8 0 0 % T
% Val: 8 8 16 8 39 47 16 0 62 0 0 0 0 24 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _